{ "name": "Condri health anxiety evidence base", "description": "Findings from the health anxiety research literature. Each record carries a verbatim quote from the source abstract, a DOI, and a PubMed ID.", "url": "https://condri.app/research/questions/", "license": { "ours": "https://creativecommons.org/licenses/by/4.0/", "whatIsOurs": "Our selection, classification, extracted figures and verification records are CC BY 4.0, attribution to Condri.", "whatIsNotOurs": "Bibliographic metadata (titles, authors, journals, years, DOIs, PubMed IDs) comes from PubMed, which NLM makes freely available. Abstracts are the copyright of their publishers and are NOT redistributed here: we index them for search and quote individual sentences with attribution, and link to PubMed or the publisher for the full text." }, "attribution": "Condri — https://condri.app", "updated": "2026-07-19", "verification": { "method": "Every quote is matched character-for-character against the paper's abstract as retrieved from PubMed and stored locally. A finding is only published if that match succeeds.", "quoteSource": "PubMed abstracts retrieved via NCBI E-utilities", "extraction": "Quotes are lifted verbatim from stored abstracts by a script, not summarised by a language model.", "corpusQuery": "(\"health anxiety\"[Title/Abstract] OR hypochondriasis[Title/Abstract] OR \"illness anxiety disorder\"[Title/Abstract] OR hypochondriacal[Title/Abstract] OR \"hypochondriasis\"[MeSH Terms])", "corpusSize": 10657, "corpusCoreSize": 4780, "temporalCoverage": "1934-2026", "knownLimits": [ "No randomised controlled trial of any smartphone app for health anxiety exists, including ours.", "Waitlist-controlled effect sizes are systematically larger than active-controlled ones and should not be compared directly.", "There is no dedicated NICE guideline for health anxiety; CG113 covers generalised anxiety disorder and panic disorder.", "Publication bias has been documented in this literature; published effects are likely optimistic." ] }, "counts": { "findings": 210, "randomisedControlledTrials": 171, "metaAnalyses": 48, "systematicReviews": 40, "papersWithDoi": 9219, "papersWithFreeFullText": 3052 }, "topics": [ "treatment", "prevalence", "cost", "mechanism", "assessment" ], "findings": [ { "id": "651966e8d86c8ad9", "topic": "assessment", "quote": "Internal consistency and test-retest reliability were 0.74, 0.81, respectively. 5.8% fall in the moderate level of cyberchondria and 2.1% of participants were found to have high level of cyberchondria.", "quotedFrom": "abstract", "source": { "title": "Psychometric properties and factor structure of the short form of the cyberchondria severity scale (CSS-12) amongst Indian adults.", "citation": "Dharshini R, Sharma MK, Anand N et al.. Psychometric properties and factor structure of the short form of the cyberchondria severity scale (CSS-12) amongst Indian adults.. Indian journal of psychiatry, 2025.", "journal": "Indian journal of psychiatry", "year": 2025, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "41503078", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41503078/", "pmcid": "PMC12774319", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12774319/" } }, { "id": "6e65e07f6630e0be", "topic": "assessment", "quote": "RESULTS: The mean participant age was 48.8 years (SD = 17.3), and 54.6 % were female.", "quotedFrom": "abstract", "source": { "title": "Reliability and validation of the Japanese version of the somatic symptom disorder-B criteria scale (J-SSD-12).", "citation": "Tominaga T, Nagoshi Y, Iwahara A et al.. Reliability and validation of the Japanese version of the somatic symptom disorder-B criteria scale (J-SSD-12).. General hospital psychiatry, 2025.", "journal": "General hospital psychiatry", "year": 2025, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "41101063", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41101063/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "da314589cd2988f5", "topic": "assessment", "quote": "Women showed markedly higher levels of HA than men (effect size: d = 0.40), and patients aged 60 years and above reported lower levels of HA than younger patients (d = -0.32).", "quotedFrom": "abstract", "source": { "title": "Health anxiety in cancer patients, assessed with the Whiteley Index.", "citation": "Hinz A, Ernst M, Schulte T et al.. Health anxiety in cancer patients, assessed with the Whiteley Index.. Journal of psychosomatic research, 2025.", "journal": "Journal of psychosomatic research", "year": 2025, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "39705898", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/39705898/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "6e2fd90233b0b99a", "topic": "assessment", "quote": "We examined item response distribution, floor and ceiling effects, and construct validity of four different one-factor models of the WI (an 8-item model, the widely used WI-7, a revised 7-item version (WI-7-R), and a 6-item version (WI-6-R)) in a population-based sample of adolescents, using data from the 16-17-year follow-up of the Copenhagen Child Cohort 2000 (N = 2521, 16-17 years old).", "quotedFrom": "abstract", "source": { "title": "Can the Whiteley Index be used to assess health anxiety in adolescents from the general population?", "citation": "Duholm CS, Højgaard DRMA, Ørnbøl E et al.. Can the Whiteley Index be used to assess health anxiety in adolescents from the general population?. Journal of psychosomatic research, 2024.", "journal": "Journal of psychosomatic research", "year": 2024, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "39426339", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/39426339/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5041867657c43f78", "topic": "assessment", "quote": "Female patients also scored significantly higher than male patients on the SHAI total score (U = 5232.500, p = 0.012), thought intrusion subscale (U = 5189.00, p = 0.008) and fear of illness subscale (U = 5069.500, p = 0.018).", "quotedFrom": "abstract", "source": { "title": "Persian version of the Short Health Anxiety Inventory (SHAI) for patients with cancer: Evaluation of psychometric properties, factor structure, and association with related constructs.", "citation": "Poshtan MM, Aflakseir A, Witthöft M et al.. Persian version of the Short Health Anxiety Inventory (SHAI) for patients with cancer: Evaluation of psychometric properties, factor structure, and association with related constructs.. Journal of psychosomatic research, 2024.", "journal": "Journal of psychosomatic research", "year": 2024, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "39423464", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/39423464/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "66ca58051eebb57d", "topic": "assessment", "quote": "RESULTS: A two-factor model (thought intrusion and fear of illness) provided the best fit for the data (SBχ2 (64) = 114.346, p < 0.001, CFI = 0.944, GFI = 0.908, RMSEA = 0.065).", "quotedFrom": "abstract", "source": { "title": "Persian version of the Short Health Anxiety Inventory (SHAI) for patients with cancer: Evaluation of psychometric properties, factor structure, and association with related constructs.", "citation": "Poshtan MM, Aflakseir A, Witthöft M et al.. Persian version of the Short Health Anxiety Inventory (SHAI) for patients with cancer: Evaluation of psychometric properties, factor structure, and association with related constructs.. Journal of psychosomatic research, 2024.", "journal": "Journal of psychosomatic research", "year": 2024, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "39423464", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/39423464/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "1d00e8c2e36a3069", "topic": "assessment", "quote": "Conventional taxometric analyses as well as comparison curve fit indices (CCFI) profile analyses (MAMBAC and MAXSLOPE procedures) were calculated with two datasets of the German adult population assessing the Whiteley Index (WI-14, N = 2,072; WI-7, N = 2,498).", "quotedFrom": "abstract", "source": { "title": "Further Evidence for a Dimensional Latent Structure of Health Anxiety: Taxometric Analyses of the Whiteley Index Based on Two German Representative Samples.", "citation": "Bräscher AK, Brähler E, Häuser W et al.. Further Evidence for a Dimensional Latent Structure of Health Anxiety: Taxometric Analyses of the Whiteley Index Based on Two German Representative Samples.. Assessment, 2024.", "journal": "Assessment", "year": 2024, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "38159038", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/38159038/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "df0a8916dc76e007", "topic": "assessment", "quote": "RESULTS: Inter-scale correlations were high (rs ≥ 0.90 and ≥ 0.88 in adjusted analyses), and the scree plot of the joint factor analysis spoke for a unifactorial solution where 89/105 items (85%) had loadings ≥ 0.40.", "quotedFrom": "abstract", "source": { "title": "Joint factor analysis and approximate equipercentile linking of common trait health anxiety measures: a cross-sectional study of the 14-, 18- and 64-item health anxiety inventory, the illness attitude scale, and the 14-item Whiteley Index.", "citation": "Axelsson E, Österman S, Hedman-Lagerlöf E. Joint factor analysis and approximate equipercentile linking of common trait health anxiety measures: a cross-sectional study of the 14-, 18- and 64-item health anxiety inventory, the illness attitude scale, and the 14-item Whiteley Index.. BMC psychiatry, 2023.", "journal": "BMC psychiatry", "year": 2023, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "37674135", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37674135/", "pmcid": "PMC10483785", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483785/" } }, { "id": "12e8c388417f3aee", "topic": "assessment", "quote": "Cross-sectional data from all participants were pooled (N = 423) and we conducted a joint factor analysis and approximate equipercentile linking of the WI-14, IAS, HAI-64, HAI-18, and HAI-14.", "quotedFrom": "abstract", "source": { "title": "Joint factor analysis and approximate equipercentile linking of common trait health anxiety measures: a cross-sectional study of the 14-, 18- and 64-item health anxiety inventory, the illness attitude scale, and the 14-item Whiteley Index.", "citation": "Axelsson E, Österman S, Hedman-Lagerlöf E. Joint factor analysis and approximate equipercentile linking of common trait health anxiety measures: a cross-sectional study of the 14-, 18- and 64-item health anxiety inventory, the illness attitude scale, and the 14-item Whiteley Index.. BMC psychiatry, 2023.", "journal": "BMC psychiatry", "year": 2023, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "37674135", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37674135/", "pmcid": "PMC10483785", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10483785/" } }, { "id": "7df8067c5b013e18", "topic": "assessment", "quote": "The OCS was predicted by CRBS (β = 0.19, p < 0.001), SAVE-9 (β = 0.45, p < 0.001), UGRS (β = 0.16, p = 0.010), and PGS (β = 0.16, p = 0.010, adjusted R2  = 0.49, F = 52.9, p < 0.001).", "quotedFrom": "abstract", "source": { "title": "Validation of the Korean version of the Utrecht Grief Rumination Scale and its relationship with COVID-related hypochondriasis among healthcare workers who witnessed patient deaths.", "citation": "Kim JH, Chung S. Validation of the Korean version of the Utrecht Grief Rumination Scale and its relationship with COVID-related hypochondriasis among healthcare workers who witnessed patient deaths.. Brain and behavior, 2023.", "journal": "Brain and behavior", "year": 2023, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "37667549", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37667549/", "pmcid": "PMC10570490", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570490/" } }, { "id": "4fbce132271bac35", "topic": "assessment", "quote": "The optimal cut point for the SSD-12 was 22 (sensitivity 75.9%, specificity 63.6%).", "quotedFrom": "abstract", "source": { "title": "Diagnostic accuracy of the Dutch version of the Somatic Symptom Disorder - B Criteria Scale (SSD-12) compared to the Whiteley Index (WI) and PHQ-15 in a clinical population.", "citation": "van der Feltz-Cornelis CM, Sweetman J, van Eck van der Sluijs JF et al.. Diagnostic accuracy of the Dutch version of the Somatic Symptom Disorder - B Criteria Scale (SSD-12) compared to the Whiteley Index (WI) and PHQ-15 in a clinical population.. Journal of psychosomatic research, 2023.", "journal": "Journal of psychosomatic research", "year": 2023, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "37607421", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37607421/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "e86a439602770937", "topic": "assessment", "quote": "The CSS-12 score was positively associated with anxiety (r = 0.10; p = 0.003) (convergent validity), OCD (r = 0.11; p = 0.016) and stress (r = 0.35; p < 0.001) (concurrent validity).", "quotedFrom": "abstract", "source": { "title": "Validation of the Arabic version of the cyberchondria severity scale 12 items (CSS-12-Ar) among a sample of Lebanese adults.", "citation": "Hallit S, Rogoza R, Abi Semaan C et al.. Validation of the Arabic version of the cyberchondria severity scale 12 items (CSS-12-Ar) among a sample of Lebanese adults.. BMC psychiatry, 2023.", "journal": "BMC psychiatry", "year": 2023, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "37612590", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37612590/", "pmcid": "PMC10463298", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463298/" } }, { "id": "5ad37d0094a9dfdb", "topic": "assessment", "quote": "RESULTS: 449 participants enrolled in this study (mean age: 24.34 ± 8.22 years, 70.6% females).", "quotedFrom": "abstract", "source": { "title": "Validation of the Arabic version of the cyberchondria severity scale 12 items (CSS-12-Ar) among a sample of Lebanese adults.", "citation": "Hallit S, Rogoza R, Abi Semaan C et al.. Validation of the Arabic version of the cyberchondria severity scale 12 items (CSS-12-Ar) among a sample of Lebanese adults.. BMC psychiatry, 2023.", "journal": "BMC psychiatry", "year": 2023, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "37612590", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37612590/", "pmcid": "PMC10463298", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463298/" } }, { "id": "d48c5b7d52fa335b", "topic": "assessment", "quote": "The optimal cut-off scores on the SHAI-14 were 22 in the psychiatric context, 29 in a setting with low prevalence of psychiatric disorders and 18 versus healthy controls.", "quotedFrom": "abstract, Results", "source": { "title": "The 14-item short health anxiety inventory (SHAI-14) used as a screening tool: appropriate interpretation and diagnostic accuracy of the Swedish version.", "citation": "Osterman S, Axelsson E, et al. BMC Psychiatry 22:701, 2022", "journal": "BMC psychiatry", "year": 2022, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "36376898", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36376898/", "pmcid": "PMC9664720", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664720/" } }, { "id": "5f1ad1c3ce531877", "topic": "assessment", "quote": "a score under 18 on the instrument is probably the best cut-off to use in order to estimate diagnostic remission", "quotedFrom": "full text, Discussion", "source": { "title": "The 14-item short health anxiety inventory (SHAI-14) used as a screening tool: appropriate interpretation and diagnostic accuracy of the Swedish version.", "citation": "Osterman S, Axelsson E, et al. BMC Psychiatry 22:701, 2022", "journal": "BMC psychiatry", "year": 2022, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "36376898", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36376898/", "pmcid": "PMC9664720", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664720/" } }, { "id": "c59271e878b5e200", "topic": "assessment", "quote": "SHAI-14 scores of 0-27 represented no or mild health anxiety, 28-32 moderate health anxiety and 33-42 substantial health anxiety.", "quotedFrom": "abstract, Results", "source": { "title": "The 14-item short health anxiety inventory (SHAI-14) used as a screening tool: appropriate interpretation and diagnostic accuracy of the Swedish version.", "citation": "Osterman S, Axelsson E, et al. BMC Psychiatry 22:701, 2022", "journal": "BMC psychiatry", "year": 2022, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "36376898", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36376898/", "pmcid": "PMC9664720", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664720/" } }, { "id": "5f0593c6e598f5bb", "topic": "assessment", "quote": "Using the ICD-10 classification, 153 patients (34.6%) had a personality disorder, with 83 (54.2%) having anxious or dependent personality disorder, 20 (13.1%) having an anankastic disorder, but also with 66 (43.1%) having mixed disorder.", "quotedFrom": "abstract", "source": { "title": "Influence of apparently negative personality characteristics on the long-term outcome of health anxiety: Secondary analysis of a randomized controlled trial.", "citation": "Tyrer P, Wang D, Tyrer H et al.. Influence of apparently negative personality characteristics on the long-term outcome of health anxiety: Secondary analysis of a randomized controlled trial.. Personality and mental health, 2021.", "journal": "Personality and mental health", "year": 2021, "studyDesign": "rct", "doi": "10.1002/pmh.1496", "doiUrl": "https://doi.org/10.1002/pmh.1496", "doiVerifiedAgainstCrossref": true, "pmid": "32985777", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32985777/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "df4acd8add1dfc0e", "topic": "assessment", "quote": "RESULTS: At baseline, 381 (86%) had some personality dysfunction, mainly at the lower level of personality difficulty (not formally a disorder).", "quotedFrom": "abstract", "source": { "title": "Influence of apparently negative personality characteristics on the long-term outcome of health anxiety: Secondary analysis of a randomized controlled trial.", "citation": "Tyrer P, Wang D, Tyrer H et al.. Influence of apparently negative personality characteristics on the long-term outcome of health anxiety: Secondary analysis of a randomized controlled trial.. Personality and mental health, 2021.", "journal": "Personality and mental health", "year": 2021, "studyDesign": "rct", "doi": "10.1002/pmh.1496", "doiUrl": "https://doi.org/10.1002/pmh.1496", "doiVerifiedAgainstCrossref": true, "pmid": "32985777", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32985777/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "bf03f7d8824e1f8c", "topic": "assessment", "quote": "The inter-rater agreement rate regarding the presence or absence of a diagnosis was 95.2% for hypochondriasis and 92.6% for dysmorphophobia.", "quotedFrom": "abstract", "source": { "title": "Validity and reliability of the diagnostic codes for hypochondriasis and dysmorphophobia in the Swedish National Patient Register: a retrospective chart review.", "citation": "Rautio D, Vilaplana-Pérez A, Gumpert M et al.. Validity and reliability of the diagnostic codes for hypochondriasis and dysmorphophobia in the Swedish National Patient Register: a retrospective chart review.. BMJ open, 2021.", "journal": "BMJ open", "year": 2021, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "34873001", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34873001/", "pmcid": "PMC8650471", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650471/" } }, { "id": "61bb262f10c8e026", "topic": "assessment", "quote": "Sixty-seven hypochondriasis files (79.8%) and 111 dysmorphophobia files (91.0%) were considered 'true positive' cases (PPV=0.80 and PPV=0.91, respectively).", "quotedFrom": "abstract", "source": { "title": "Validity and reliability of the diagnostic codes for hypochondriasis and dysmorphophobia in the Swedish National Patient Register: a retrospective chart review.", "citation": "Rautio D, Vilaplana-Pérez A, Gumpert M et al.. Validity and reliability of the diagnostic codes for hypochondriasis and dysmorphophobia in the Swedish National Patient Register: a retrospective chart review.. BMJ open, 2021.", "journal": "BMJ open", "year": 2021, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "34873001", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34873001/", "pmcid": "PMC8650471", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650471/" } }, { "id": "3ec38e9b12ad03d3", "topic": "assessment", "quote": "A one-factor 6-item model (including the item on obsessive illness rumination and excluding two items concerning somatic symptoms) was chosen as the optimal model and presented good criterion validity: AUC 0.88 (95%CI(0.84;0.92)).", "quotedFrom": "abstract", "source": { "title": "Detection of illness worry in the general population: A specific item on illness rumination improves the Whiteley Index.", "citation": "Carstensen TBW, Ørnbøl E, Fink P et al.. Detection of illness worry in the general population: A specific item on illness rumination improves the Whiteley Index.. Journal of psychosomatic research, 2020.", "journal": "Journal of psychosomatic research", "year": 2020, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "32950761", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32950761/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "882894fae993a36c", "topic": "assessment", "quote": "The SSD-12 sum score was significantly associated with somatic symptom burden (Patient Health Questionnaire-15: r = 0.52, p < .001), health anxiety (Whiteley Index-7: r = 0.82, p < .001), depressive symptoms (Patient Health Questionnaire-9: r = 0.63, p < .001), general anxiety (General Anxiety Disorder-7: r = 0.64, p < .001), health-related quality of life (physical component score of SF-12: r = -0.49, p < .001; mental component score of SF-12: r = -0.61, p < .001), and health-related disabilities (World Health Organization Disability Assessment Schedule: r = 0.56, p < .001).", "quotedFrom": "abstract", "source": { "title": "Validation of the Chinese Version of the Somatic Symptom Disorder-B Criteria Scale for Detecting DSM-5 Somatic Symptom Disorders: A Multicenter Study.", "citation": "Li T, Wei J, Fritzsche K et al.. Validation of the Chinese Version of the Somatic Symptom Disorder-B Criteria Scale for Detecting DSM-5 Somatic Symptom Disorders: A Multicenter Study.. Psychosomatic medicine, 2020.", "journal": "Psychosomatic medicine", "year": 2020, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "32058460", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32058460/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "8a42e29b3bff4376", "topic": "assessment", "quote": "Confirmatory factor analyses replicated a three-factor structure that reflects the cognitive, affective, and behavioral aspects (Comparative Fit Index = 0.963, Tucker-Lewis Index = 0.952, root mean square error of approximation = 0.08, 90% confidence interval = 0.08-0.09), but was also consistent with a general one-factor model of the SSD-12 (Comparative Fit Index = 0.957, Tucker-Lewis Index = 0.948, root mean square error of approximation = 0.09, 90% confidence interval = 0.08-0.10).", "quotedFrom": "abstract", "source": { "title": "Validation of the Chinese Version of the Somatic Symptom Disorder-B Criteria Scale for Detecting DSM-5 Somatic Symptom Disorders: A Multicenter Study.", "citation": "Li T, Wei J, Fritzsche K et al.. Validation of the Chinese Version of the Somatic Symptom Disorder-B Criteria Scale for Detecting DSM-5 Somatic Symptom Disorders: A Multicenter Study.. Psychosomatic medicine, 2020.", "journal": "Psychosomatic medicine", "year": 2020, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "32058460", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32058460/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "d045f8287fffc8b7", "topic": "assessment", "quote": "Results supported a bifactor model of the MIHT in three different samples (i.e., unselected based on current medical status [n = 824], and those with [n = 348] and without [n = 354] a self-reported medical condition).", "quotedFrom": "abstract", "source": { "title": "Multidimensional Inventory of Hypochondriacal Traits: An Examination of a Bifactor Model and Measurement Invariance Between Those With and Without a Self-Reported Medical Condition.", "citation": "Bardeen JR, Fergus TA. Multidimensional Inventory of Hypochondriacal Traits: An Examination of a Bifactor Model and Measurement Invariance Between Those With and Without a Self-Reported Medical Condition.. Assessment, 2020.", "journal": "Assessment", "year": 2020, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "28800717", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28800717/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "11317131813919fd", "topic": "assessment", "quote": "The SAPH demonstrated good interrater reliability (ICC(1,2)  = .88, p < .001, 95% CI [.81, .92]) and internal consistency (α = .94).", "quotedFrom": "abstract", "source": { "title": "The assessment of cognitive-behavioral therapy skills in patients diagnosed with health anxiety: Development and pilot study on an observer-based rating scale.", "citation": "Ay DS, Kühne F, Weck F. The assessment of cognitive-behavioral therapy skills in patients diagnosed with health anxiety: Development and pilot study on an observer-based rating scale.. Clinical psychology & psychotherapy, 2019.", "journal": "Clinical psychology & psychotherapy", "year": 2019, "studyDesign": "other", "doi": "10.1002/cpp.2387", "doiUrl": "https://doi.org/10.1002/cpp.2387", "doiVerifiedAgainstCrossref": true, "pmid": "31218759", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31218759/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "0883a5b84b35614b", "topic": "assessment", "quote": "Results from a receiver operating characteristic (ROC) analysis indicated that a cutoff score of 18 on the WI-6 adequately balanced sensitivity (75%) and specificity (77%).", "quotedFrom": "abstract", "source": { "title": "Examining the Whiteley Index-6 as a screener for DSM-5 presentations of severe health anxiety in primary care.", "citation": "Fergus TA, Kelley LP, Griggs JO. Examining the Whiteley Index-6 as a screener for DSM-5 presentations of severe health anxiety in primary care.. Journal of psychosomatic research, 2019.", "journal": "Journal of psychosomatic research", "year": 2019, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "31677549", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31677549/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "28e703ce8af67a56", "topic": "assessment", "quote": "The area under the curve (AUC) indicated the WI-6 did a reasonable job discriminating between the two groups (AUC = 0.83, p < .001, 95% confidence interval = 0.77-0.89).", "quotedFrom": "abstract", "source": { "title": "Examining the Whiteley Index-6 as a screener for DSM-5 presentations of severe health anxiety in primary care.", "citation": "Fergus TA, Kelley LP, Griggs JO. Examining the Whiteley Index-6 as a screener for DSM-5 presentations of severe health anxiety in primary care.. Journal of psychosomatic research, 2019.", "journal": "Journal of psychosomatic research", "year": 2019, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "31677549", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31677549/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "20e67cbff0023e4f", "topic": "assessment", "quote": "Participants were undergraduate students from two UK universities (N = 661, 73% female, Mage = 22.19 years, SD = 5.88).", "quotedFrom": "abstract", "source": { "title": "The CSS-12: Development and Validation of a Short-Form Version of the Cyberchondria Severity Scale.", "citation": "McElroy E, Kearney M, Touhey J et al.. The CSS-12: Development and Validation of a Short-Form Version of the Cyberchondria Severity Scale.. Cyberpsychology, behavior and social networking, 2019.", "journal": "Cyberpsychology, behavior and social networking", "year": 2019, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "31013440", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31013440/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "47cd45662de65dea", "topic": "assessment", "quote": "Competence of therapists-in-training was assessed in a random sample of n = 30 videos on cognitive behavioural therapy including patients diagnosed with hypochondriasis.", "quotedFrom": "abstract", "source": { "title": "Strengthening competence of therapists-in-training in the treatment of health anxiety (hypochondriasis): Validation of the Assessment of Core CBT Skills (ACCS).", "citation": "Kühne F, Lacki FJ, Muse K et al.. Strengthening competence of therapists-in-training in the treatment of health anxiety (hypochondriasis): Validation of the Assessment of Core CBT Skills (ACCS).. Clinical psychology & psychotherapy, 2019.", "journal": "Clinical psychology & psychotherapy", "year": 2019, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "30793415", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/30793415/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "df5462110ca74793", "topic": "assessment", "quote": "Two of three raters independently assessed the competences demonstrated in the entire, active treatment sessions (n = 60).", "quotedFrom": "abstract", "source": { "title": "Strengthening competence of therapists-in-training in the treatment of health anxiety (hypochondriasis): Validation of the Assessment of Core CBT Skills (ACCS).", "citation": "Kühne F, Lacki FJ, Muse K et al.. Strengthening competence of therapists-in-training in the treatment of health anxiety (hypochondriasis): Validation of the Assessment of Core CBT Skills (ACCS).. Clinical psychology & psychotherapy, 2019.", "journal": "Clinical psychology & psychotherapy", "year": 2019, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "30793415", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/30793415/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "c293be4c987ff0cb", "topic": "assessment", "quote": "Convergent (pregnancy-related anxiety [r = 0.56, p = .0001], parental health anxiety [r = 0.53, p = .0001], anxiety [r = 0.57, p = .0001], anxiety sensitivity [r = 0.28, p = .004] and intolerance of uncertainty [r = 0.29, p = .003]) and divergent (parental depression [r = 0.16, p = .12]) validity was evidenced with additional measures of interest.", "quotedFrom": "abstract", "source": { "title": "Fetal health anxiety: development and psychometric properties of the fetal health anxiety inventory.", "citation": "Reiser SJ, Wright KD. Fetal health anxiety: development and psychometric properties of the fetal health anxiety inventory.. Journal of psychosomatic obstetrics and gynaecology, 2019.", "journal": "Journal of psychosomatic obstetrics and gynaecology", "year": 2019, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "30089227", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/30089227/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "efddf36fc1148891", "topic": "assessment", "quote": "In the EFA, 4- and 5-factor model showed cumulative percentile of variance of 60% or more.", "quotedFrom": "abstract", "source": { "title": "Reliability and Validity of the Korean Version of Health Anxiety Questionnaire.", "citation": "Hwang KS, Jang SH, Lee HJ et al.. Reliability and Validity of the Korean Version of Health Anxiety Questionnaire.. Psychiatry investigation, 2018.", "journal": "Psychiatry investigation", "year": 2018, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "30301306", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/30301306/", "pmcid": "PMC6212705", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212705/" } }, { "id": "83ca7bb300c8df9b", "topic": "assessment", "quote": "A Portuguese adolescent cohort ( N = 629) and a comparative Spanish adolescent cohort ( N = 1502) were evaluated.", "quotedFrom": "abstract", "source": { "title": "Portuguese validation of the Short Health Anxiety Inventory: Factor structure, reliability, and factor invariance.", "citation": "Morales A, Reis S, Espada JP et al.. Portuguese validation of the Short Health Anxiety Inventory: Factor structure, reliability, and factor invariance.. Journal of health psychology, 2018.", "journal": "Journal of health psychology", "year": 2018, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "27682334", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/27682334/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "6e34b8ed8e3d414a", "topic": "assessment", "quote": "Persons with clinically significant health anxiety (n = 52) and healthy controls (n = 52) were interviewed using the HPDI.", "quotedFrom": "abstract", "source": { "title": "The health preoccupation diagnostic interview: inter-rater reliability of a structured interview for diagnostic assessment of DSM-5 somatic symptom disorder and illness anxiety disorder.", "citation": "Axelsson E, Andersson E, Ljótsson B et al.. The health preoccupation diagnostic interview: inter-rater reliability of a structured interview for diagnostic assessment of DSM-5 somatic symptom disorder and illness anxiety disorder.. Cognitive behaviour therapy, 2016.", "journal": "Cognitive behaviour therapy", "year": 2016, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "27096407", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/27096407/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "d4bdc8eafc36dc4c", "topic": "assessment", "quote": "Inclusion criteria were fulfilled by n = 500 participants (age 29.1 ± 10.4 years, 73.6 % women).", "quotedFrom": "abstract", "source": { "title": "The Cyberchondria Severity Scale (CSS): German Validation and Development of a Short Form.", "citation": "Barke A, Bleichhardt G, Rief W et al.. The Cyberchondria Severity Scale (CSS): German Validation and Development of a Short Form.. International journal of behavioral medicine, 2016.", "journal": "International journal of behavioral medicine", "year": 2016, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "26931780", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26931780/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "8511ec23d94e2c4e", "topic": "assessment", "quote": "A brief version with 15 items was developed (CSS-15) and validated in a second sample (n = 292; age 24.2 ± 4.1 years, 76.4 % women).", "quotedFrom": "abstract", "source": { "title": "The Cyberchondria Severity Scale (CSS): German Validation and Development of a Short Form.", "citation": "Barke A, Bleichhardt G, Rief W et al.. The Cyberchondria Severity Scale (CSS): German Validation and Development of a Short Form.. International journal of behavioral medicine, 2016.", "journal": "International journal of behavioral medicine", "year": 2016, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "26931780", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26931780/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "38e3a681ab2e8091", "topic": "assessment", "quote": "SSD-12 total sum score was significantly associated with somatic symptom burden (r = 0.47, p < .001) and health anxiety (r = 0.71, p < .001), and moderately associated with general anxiety (r = 0.35, p < .001) and depressive symptoms (r = 0.22, p < .001).", "quotedFrom": "abstract", "source": { "title": "Development and Validation of the Somatic Symptom Disorder-B Criteria Scale (SSD-12).", "citation": "Toussaint A, Murray AM, Voigt K et al.. Development and Validation of the Somatic Symptom Disorder-B Criteria Scale (SSD-12).. Psychosomatic medicine, 2016.", "journal": "Psychosomatic medicine", "year": 2016, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "26461855", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26461855/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5b468273f2a0191c", "topic": "assessment", "quote": "Confirmatory factor analyses suggested that a three-factorial structure that reflects the three psychological criteria interpreted as cognitive, affective, and behavioral aspects (n = 663, Comparative Fit Index > 0.99, Tucker-Lewis Index > 0.99, Root Mean Square Error of Approximation = 0.06, 90% confidence interval = 0.01-0.08).", "quotedFrom": "abstract", "source": { "title": "Development and Validation of the Somatic Symptom Disorder-B Criteria Scale (SSD-12).", "citation": "Toussaint A, Murray AM, Voigt K et al.. Development and Validation of the Somatic Symptom Disorder-B Criteria Scale (SSD-12).. Psychosomatic medicine, 2016.", "journal": "Psychosomatic medicine", "year": 2016, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "26461855", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26461855/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "93438892cbe3a24e", "topic": "assessment", "quote": "Results also indicated that participants worried about their mental health and physical health equally, and that almost 9% of participants reported levels of mental health anxiety that were potentially problematic.", "quotedFrom": "abstract", "source": { "title": "A Preliminary Investigation into Worry about Mental Health: Development of the Mental Health Anxiety Inventory.", "citation": "Commons D, Greenwood KM, Anderson RA. A Preliminary Investigation into Worry about Mental Health: Development of the Mental Health Anxiety Inventory.. Behavioural and cognitive psychotherapy, 2016.", "journal": "Behavioural and cognitive psychotherapy", "year": 2016, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "26299438", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26299438/", "pmcid": "PMC4877520", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877520/" } }, { "id": "7c18d2e93986961e", "topic": "assessment", "quote": "The test-retest correlation coefficients were, respectively, 0.598 (P<0.001), 0.539 (P<0.001), and 0.691 (P<0.001).", "quotedFrom": "abstract", "source": { "title": "The reliability and validity of a Chinese-version Short Health Anxiety Inventory: an investigation of university students.", "citation": "Zhang Y, Liu R, Li G et al.. The reliability and validity of a Chinese-version Short Health Anxiety Inventory: an investigation of university students.. Neuropsychiatric disease and treatment, 2015.", "journal": "Neuropsychiatric disease and treatment", "year": 2015, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "26213472", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26213472/", "pmcid": "PMC4509540", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509540/" } }, { "id": "de76232ee48ba53f", "topic": "assessment", "quote": "Convergent validities were respectively 0.389-0.453, 0.389-0.410, and 0.250-0.401, and discriminant validities were -5.689 (P<0.001), -5.614 (P<0.001), and -3.709 (P<0.001).", "quotedFrom": "abstract", "source": { "title": "The reliability and validity of a Chinese-version Short Health Anxiety Inventory: an investigation of university students.", "citation": "Zhang Y, Liu R, Li G et al.. The reliability and validity of a Chinese-version Short Health Anxiety Inventory: an investigation of university students.. Neuropsychiatric disease and treatment, 2015.", "journal": "Neuropsychiatric disease and treatment", "year": 2015, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "26213472", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26213472/", "pmcid": "PMC4509540", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509540/" } }, { "id": "dda48b4b76722fa3", "topic": "assessment", "quote": "Sensitivity and specificity were high, ranging from 92.6 to 99.4%.", "quotedFrom": "abstract", "source": { "title": "Optimal cut-off points on the health anxiety inventory, illness attitude scales and whiteley index to identify severe health anxiety.", "citation": "Hedman E, Lekander M, Ljótsson B et al.. Optimal cut-off points on the health anxiety inventory, illness attitude scales and whiteley index to identify severe health anxiety.. PloS one, 2015.", "journal": "PloS one", "year": 2015, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "25849477", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25849477/", "pmcid": "PMC4388630", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388630/" } }, { "id": "d1afac9c9b326d09", "topic": "assessment", "quote": "Positive and negative predictive values ranged from 91.6 to 99.4% using unadjusted prevalence rates.", "quotedFrom": "abstract", "source": { "title": "Optimal cut-off points on the health anxiety inventory, illness attitude scales and whiteley index to identify severe health anxiety.", "citation": "Hedman E, Lekander M, Ljótsson B et al.. Optimal cut-off points on the health anxiety inventory, illness attitude scales and whiteley index to identify severe health anxiety.. PloS one, 2015.", "journal": "PloS one", "year": 2015, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "25849477", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25849477/", "pmcid": "PMC4388630", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388630/" } }, { "id": "3086a26b24459df6", "topic": "assessment", "quote": "Participants (N=526) from a community sample completed the CSS via online crowd sourcing.", "quotedFrom": "abstract", "source": { "title": "Validation of the Cyberchondria Severity Scale (CSS): replication and extension with bifactor modeling.", "citation": "Norr AM, Allan NP, Boffa JW et al.. Validation of the Cyberchondria Severity Scale (CSS): replication and extension with bifactor modeling.. Journal of anxiety disorders, 2015.", "journal": "Journal of anxiety disorders", "year": 2015, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "25734759", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25734759/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "8ce794c6b0eeddbf", "topic": "assessment", "quote": "Using confirmatory factor analysis (CFA), the postulated four-factor structure of the MIHT was found in a first CFA in patients with hypochondriasis (n = 178) and in a second CFA based on a mixed sample, with other somatoform disorders (n = 27), panic disorder (n = 25), and healthy controls (n = 31) added to the original group of patients with hypochondriasis (n = 178).", "quotedFrom": "abstract", "source": { "title": "The multidimensional inventory of hypochondriacal traits: factor structure, specificity, reliability, and validity in patients with hypochondriasis.", "citation": "Witthöft M, Weck F, Gropalis M. The multidimensional inventory of hypochondriacal traits: factor structure, specificity, reliability, and validity in patients with hypochondriasis.. Assessment, 2015.", "journal": "Assessment", "year": 2015, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "25092716", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25092716/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "61419c23759352ce", "topic": "assessment", "quote": "A sample of undergraduate students (N = 208; 64% female) completed a pilot version of the cyberchondria severity scale (CSS) along with the short form version of the depression, anxiety and stress scale (DASS-21).", "quotedFrom": "abstract", "source": { "title": "The development and initial validation of the cyberchondria severity scale (CSS).", "citation": "McElroy E, Shevlin M. The development and initial validation of the cyberchondria severity scale (CSS).. Journal of anxiety disorders, 2014.", "journal": "Journal of anxiety disorders", "year": 2014, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "24508033", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24508033/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5184db25951ec051", "topic": "assessment", "quote": "Study groups consisted of in- or out-patients with somatoform disorder (n=65), panic disorder (n=55), major depressive disorder (n=22), and healthy volunteers (n=114).", "quotedFrom": "abstract", "source": { "title": "Reliability and Validity of the Turkish Version of the Health Anxiety Inventory.", "citation": "Aydemir Ö, Kirpinar İ, Sati T et al.. Reliability and Validity of the Turkish Version of the Health Anxiety Inventory.. Noro psikiyatri arsivi, 2013.", "journal": "Noro psikiyatri arsivi", "year": 2013, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "28360565", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28360565/", "pmcid": "PMC5363424", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363424/" } }, { "id": "7f7e101029431ed0", "topic": "cost", "quote": "The economic analysis showed that, from the healthcare perspective, iACT was associated with an incremental cost-effectiveness ratio of €33 per additional case of clinically significant improvement compared with iFORUM and that, from the societal perspective, iACT dominated iFORUM because it was more effective and less expensive.", "quotedFrom": "abstract (auto-extracted verbatim)", "source": { "title": "Cost Effectiveness of Internet-Delivered Acceptance and Commitment Therapy for Patients with Severe Health Anxiety: A Randomised Controlled Trial.", "citation": "Risor BW, Frydendal DH, Villemoes MK, Nielsen CP, Rask CU, Frostholm L. PharmacoEcon Open 6(2), 2022", "journal": "PharmacoEconomics - open", "year": 2022, "studyDesign": "other", "doi": "10.1007/s41669-021-00319-x", "doiUrl": "https://doi.org/10.1007/s41669-021-00319-x", "doiVerifiedAgainstCrossref": true, "pmid": "34997899", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34997899/", "pmcid": "PMC8864054", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864054/" } }, { "id": "1c09e29df58bee64", "topic": "cost", "quote": "Meta-analyses revealed a significant association between socioeconomic status and health anxiety (r - 0.14, 95%-CI -0.18 to -0.09 (screening scales) and OR 0.63, 95%-CI 0.43 to 0.92 (diagnostic interviews)), indicating a lower risk for health anxiety in people with higher socioeconomic status.", "quotedFrom": "abstract", "source": { "title": "Social inequalities in health anxiety: A systematic review and meta-analysis.", "citation": "Barbek RME, Makowski AC, von dem Knesebeck O. Social inequalities in health anxiety: A systematic review and meta-analysis.. Journal of psychosomatic research, 2022.", "journal": "Journal of psychosomatic research", "year": 2022, "studyDesign": "meta-analysis", "doi": "10.1016/j.jpsychores.2021.110706", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2021.110706", "doiVerifiedAgainstCrossref": true, "pmid": "34954602", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34954602/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "64c2e7dcfb55541a", "topic": "cost", "quote": "In three studies (N = 2025) correlations between SD/SSD and neuroticism/negative affectivity (d = 0.22-1.041) were present.", "quotedFrom": "abstract", "source": { "title": "Somatization and Somatic Symptom Disorder and its overlap with dimensionally measured personality pathology: A systematic review.", "citation": "Macina C, Bendel R, Walter M et al.. Somatization and Somatic Symptom Disorder and its overlap with dimensionally measured personality pathology: A systematic review.. Journal of psychosomatic research, 2021.", "journal": "Journal of psychosomatic research", "year": 2021, "studyDesign": "systematic-review", "doi": "10.1016/j.jpsychores.2021.110646", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2021.110646", "doiVerifiedAgainstCrossref": true, "pmid": "34715494", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34715494/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "e71c2e18a12476cc", "topic": "cost", "quote": "Eighty-five studies comprising 3242 FSSs/SSDs patients and 2321 controls were included in the main meta-analysis; the baseline HRV value was significantly lower compared to healthy individuals (Hedges'g, -0.43; 95 % CI, -0.54 to -0.30; p < .001), with the largest effect size in fibromyalgia patients.", "quotedFrom": "abstract", "source": { "title": "Heart rate variability in patients with somatic symptom disorders and functional somatic syndromes: A systematic review and meta-analysis.", "citation": "Ying-Chih C, Yu-Chen H, Wei-Lieh H. Heart rate variability in patients with somatic symptom disorders and functional somatic syndromes: A systematic review and meta-analysis.. Neuroscience and biobehavioral reviews, 2020.", "journal": "Neuroscience and biobehavioral reviews", "year": 2020, "studyDesign": "meta-analysis", "doi": "10.1016/j.neubiorev.2020.02.007", "doiUrl": "https://doi.org/10.1016/j.neubiorev.2020.02.007", "doiVerifiedAgainstCrossref": true, "pmid": "32068033", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32068033/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "a547380bfd1a4c5e", "topic": "cost", "quote": "A significant lower HRV was also found for total variability (Hedges'g, -0.56; 95 % CI, -0.77 to -0.36) and specific parasympathetic indices (Hedges'g, -0.41, 95 % CI; -0.54 to -0.30).", "quotedFrom": "abstract", "source": { "title": "Heart rate variability in patients with somatic symptom disorders and functional somatic syndromes: A systematic review and meta-analysis.", "citation": "Ying-Chih C, Yu-Chen H, Wei-Lieh H. Heart rate variability in patients with somatic symptom disorders and functional somatic syndromes: A systematic review and meta-analysis.. Neuroscience and biobehavioral reviews, 2020.", "journal": "Neuroscience and biobehavioral reviews", "year": 2020, "studyDesign": "meta-analysis", "doi": "10.1016/j.neubiorev.2020.02.007", "doiUrl": "https://doi.org/10.1016/j.neubiorev.2020.02.007", "doiVerifiedAgainstCrossref": true, "pmid": "32068033", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32068033/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "1832008162f424d7", "topic": "cost", "quote": "Based on 19 RCTs, the pooled between-group effect on health anxiety was moderate to large (g = 0.79; 95% CI: 0.57-1.01; adjusted for publication bias: g = 0.62), with small to moderate effects on secondary symptoms and effects largely sustained 12-18 months after treatment.", "quotedFrom": "abstract", "source": { "title": "Cognitive behavior therapy for health anxiety: systematic review and meta-analysis of clinical efficacy and health economic outcomes.", "citation": "Axelsson E, Hedman-Lagerlöf E. Cognitive behavior therapy for health anxiety: systematic review and meta-analysis of clinical efficacy and health economic outcomes.. Expert review of pharmacoeconomics & outcomes research, 2019.", "journal": "Expert review of pharmacoeconomics & outcomes research", "year": 2019, "studyDesign": "meta-analysis", "doi": "10.1080/14737167.2019.1703182", "doiUrl": "https://doi.org/10.1080/14737167.2019.1703182", "doiVerifiedAgainstCrossref": true, "pmid": "31859542", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31859542/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "c28b8da124168ae2", "topic": "cost", "quote": "The pooled CBT response rate was 66%, and the remission rate 48%.", "quotedFrom": "abstract", "source": { "title": "Cognitive behavior therapy for health anxiety: systematic review and meta-analysis of clinical efficacy and health economic outcomes.", "citation": "Axelsson E, Hedman-Lagerlöf E. Cognitive behavior therapy for health anxiety: systematic review and meta-analysis of clinical efficacy and health economic outcomes.. Expert review of pharmacoeconomics & outcomes research, 2019.", "journal": "Expert review of pharmacoeconomics & outcomes research", "year": 2019, "studyDesign": "meta-analysis", "doi": "10.1080/14737167.2019.1703182", "doiUrl": "https://doi.org/10.1080/14737167.2019.1703182", "doiVerifiedAgainstCrossref": true, "pmid": "31859542", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31859542/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "4d7be5e55754aa47", "topic": "cost", "quote": "Compared to TAU, RCBT significantly reduced health anxiety at six months, maintained to 9 and 12 months (mean change difference HAI -2.81; 95% CI -5.11 to -0.50; P = 0.017).", "quotedFrom": "abstract", "source": { "title": "Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multicentre randomised controlled trial.", "citation": "Morriss R, Patel S, Malins S et al.. Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multicentre randomised controlled trial.. BMC medicine, 2019.", "journal": "BMC medicine", "year": 2019, "studyDesign": "rct", "doi": "10.1186/s12916-019-1253-5", "doiUrl": "https://doi.org/10.1186/s12916-019-1253-5", "doiVerifiedAgainstCrossref": true, "pmid": "30670044", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/30670044/", "pmcid": "PMC6343350", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343350/" } }, { "id": "ff3088d9381f2f42", "topic": "cost", "quote": "RESULTS: Of the 524 patients who were referred and assessed for trial eligibility, 470 were eligible and 156 (33%) were recruited; 78 were randomised to TAU and 78 to RCBT.", "quotedFrom": "abstract", "source": { "title": "Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multicentre randomised controlled trial.", "citation": "Morriss R, Patel S, Malins S et al.. Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multicentre randomised controlled trial.. BMC medicine, 2019.", "journal": "BMC medicine", "year": 2019, "studyDesign": "rct", "doi": "10.1186/s12916-019-1253-5", "doiUrl": "https://doi.org/10.1186/s12916-019-1253-5", "doiVerifiedAgainstCrossref": true, "pmid": "30670044", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/30670044/", "pmcid": "PMC6343350", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343350/" } }, { "id": "dbde2edcae21ae2c", "topic": "cost", "quote": "Adults (N = 132) with principal SHA were randomised to 12 weeks of G-ICBT, U-ICBT, BIB-CBT, or WLC.", "quotedFrom": "abstract", "source": { "title": "Cost-effectiveness and long-term follow-up of three forms of minimal-contact cognitive behaviour therapy for severe health anxiety: Results from a randomised controlled trial.", "citation": "Axelsson E, Andersson E, Ljótsson B et al.. Cost-effectiveness and long-term follow-up of three forms of minimal-contact cognitive behaviour therapy for severe health anxiety: Results from a randomised controlled trial.. Behaviour research and therapy, 2018.", "journal": "Behaviour research and therapy", "year": 2018, "studyDesign": "rct", "doi": "10.1016/j.brat.2018.06.002", "doiUrl": "https://doi.org/10.1016/j.brat.2018.06.002", "doiVerifiedAgainstCrossref": true, "pmid": "29936239", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/29936239/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "07ad01ac0c0aad68", "topic": "cost", "quote": "Those with no personality dysfunction showed no treatment differences (P = 0.90) and worse social function with CBT-HA compared with standard care (P<0.03) whereas all other personality groups showed greater improvement with CBT-HA maintained over 2 years (P<0.001).", "quotedFrom": "abstract", "source": { "title": "Impact of personality status on the outcomes and cost of cognitive-behavioural therapy for health anxiety.", "citation": "Sanatinia R, Wang D, Tyrer P et al.. Impact of personality status on the outcomes and cost of cognitive-behavioural therapy for health anxiety.. The British journal of psychiatry : the journal of mental science, 2016.", "journal": "The British journal of psychiatry : the journal of mental science", "year": 2016, "studyDesign": "rct", "doi": "10.1192/bjp.bp.115.173526", "doiUrl": "https://doi.org/10.1192/bjp.bp.115.173526", "doiVerifiedAgainstCrossref": true, "pmid": "27445356", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/27445356/", "pmcid": "PMC5007454", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007454/" } }, { "id": "fc5dc58bf0f1b259", "topic": "cost", "quote": "RESULTS: In total, 381 patients (86%) had some personality dysfunction with 184 (41%) satisfying the ICD criteria for personality disorder.", "quotedFrom": "abstract", "source": { "title": "Impact of personality status on the outcomes and cost of cognitive-behavioural therapy for health anxiety.", "citation": "Sanatinia R, Wang D, Tyrer P et al.. Impact of personality status on the outcomes and cost of cognitive-behavioural therapy for health anxiety.. The British journal of psychiatry : the journal of mental science, 2016.", "journal": "The British journal of psychiatry : the journal of mental science", "year": 2016, "studyDesign": "rct", "doi": "10.1192/bjp.bp.115.173526", "doiUrl": "https://doi.org/10.1192/bjp.bp.115.173526", "doiVerifiedAgainstCrossref": true, "pmid": "27445356", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/27445356/", "pmcid": "PMC5007454", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007454/" } }, { "id": "22ac44723f7b4744", "topic": "cost", "quote": "RESULTS: Both treatments led to significant reductions in gross total costs, costs of healthcare visits, direct non-medical costs and costs of domestic work cutback (p=0.000-0.035).", "quotedFrom": "abstract", "source": { "title": "Cost effectiveness of internet-based cognitive behaviour therapy and behavioural stress management for severe health anxiety.", "citation": "Hedman E, Andersson E, Ljótsson B et al.. Cost effectiveness of internet-based cognitive behaviour therapy and behavioural stress management for severe health anxiety.. BMJ open, 2016.", "journal": "BMJ open", "year": 2016, "studyDesign": "rct", "doi": "10.1136/bmjopen-2015-009327", "doiUrl": "https://doi.org/10.1136/bmjopen-2015-009327", "doiVerifiedAgainstCrossref": true, "pmid": "27113231", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/27113231/", "pmcid": "PMC4854011", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854011/" } }, { "id": "9a2eb643d0bc73c0", "topic": "cost", "quote": "At 1 year, improvement in health anxiety in the patients in the CBT-HA group was 2·98 points greater than in those in the standard care group (95% CI 1·64-4·33, p<0·0001), and twice as many patients receiving cognitive behaviour therapy achieved normal levels of health anxiety compared with those in the control group (13·9% vs 7·3%; odds ratio 2·15, 95% CI 1·09-4·23, p=0·0273).", "quotedFrom": "abstract", "source": { "title": "Clinical and cost-effectiveness of cognitive behaviour therapy for health anxiety in medical patients: a multicentre randomised controlled trial.", "citation": "Tyrer P, Cooper S, Salkovskis P et al.. Clinical and cost-effectiveness of cognitive behaviour therapy for health anxiety in medical patients: a multicentre randomised controlled trial.. Lancet (London, England), 2014.", "journal": "Lancet (London, England)", "year": 2014, "studyDesign": "rct", "doi": "10.1016/S0140-6736(13)61905-4", "doiUrl": "https://doi.org/10.1016/S0140-6736(13)61905-4", "doiVerifiedAgainstCrossref": true, "pmid": "24139977", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24139977/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "62990cd9228631b0", "topic": "cost", "quote": "Equivalence in total 2-year costs was not achieved, but the difference was not significant (adjusted mean difference £156, 95% CI -1446 to 1758, p=0·848).", "quotedFrom": "abstract", "source": { "title": "Clinical and cost-effectiveness of cognitive behaviour therapy for health anxiety in medical patients: a multicentre randomised controlled trial.", "citation": "Tyrer P, Cooper S, Salkovskis P et al.. Clinical and cost-effectiveness of cognitive behaviour therapy for health anxiety in medical patients: a multicentre randomised controlled trial.. Lancet (London, England), 2014.", "journal": "Lancet (London, England)", "year": 2014, "studyDesign": "rct", "doi": "10.1016/S0140-6736(13)61905-4", "doiUrl": "https://doi.org/10.1016/S0140-6736(13)61905-4", "doiVerifiedAgainstCrossref": true, "pmid": "24139977", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24139977/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "b15728a61675b651", "topic": "cost", "quote": "Baseline to 1-year follow-up effect sizes on the primary outcome measure were large (d = 1.71-1.95).", "quotedFrom": "abstract", "source": { "title": "Cost-effectiveness and long-term effectiveness of internet-based cognitive behaviour therapy for severe health anxiety.", "citation": "Hedman E, Andersson E, Lindefors N et al.. Cost-effectiveness and long-term effectiveness of internet-based cognitive behaviour therapy for severe health anxiety.. Psychological medicine, 2013.", "journal": "Psychological medicine", "year": 2013, "studyDesign": "rct", "doi": "10.1017/S0033291712001079", "doiUrl": "https://doi.org/10.1017/S0033291712001079", "doiVerifiedAgainstCrossref": true, "pmid": "22608115", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/22608115/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "31c4fa72d1b60f89", "topic": "cost", "quote": "Results indicate significant improvement on both measures at posttreatment and 6-month follow-up (Cohen's d = 1.03-1.72).", "quotedFrom": "abstract", "source": { "title": "Effectiveness and cost offset analysis of group CBT for hypochondriasis delivered in a psychiatric setting: an open trial.", "citation": "Hedman E, Ljótsson B, Andersson E et al.. Effectiveness and cost offset analysis of group CBT for hypochondriasis delivered in a psychiatric setting: an open trial.. Cognitive behaviour therapy, 2010.", "journal": "Cognitive behaviour therapy", "year": 2010, "studyDesign": "clinical-trial", "doi": "10.1080/16506073.2010.496460", "doiUrl": "https://doi.org/10.1080/16506073.2010.496460", "doiVerifiedAgainstCrossref": true, "pmid": "20972912", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/20972912/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "a2e801a504818944", "topic": "cost", "quote": "an estimated USD 256 billion a year in medical care costs are attributable to the incremental effect of somatization alone", "quotedFrom": "abstract", "source": { "title": null, "citation": "Barsky AJ, et al. Somatization increases medical utilization and costs independent of psychiatric and medical comorbidity. Archives of General Psychiatry, 2005.", "journal": null, "year": null, "studyDesign": null, "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "16061768", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/16061768/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "20dfd8452b0911aa", "topic": "mechanism", "quote": "A significant medium effect was found for PMC and health anxiety (r = .36, p < 0.0001, 95% CI:.29 ≤ r ≤ .43), whereas for NMC the effect was large (r = .52, p < 0.0001, 95% CI:.46 ≤ r ≤ .58).", "quotedFrom": "abstract", "source": { "title": "Do metacognitions contribute to pathological health anxiety? A systematic review and meta-analysis.", "citation": "Ivan L, Foerster P, Bermpohl FMG et al.. Do metacognitions contribute to pathological health anxiety? A systematic review and meta-analysis.. PloS one, 2025.", "journal": "PloS one", "year": 2025, "studyDesign": "meta-analysis", "doi": "10.1371/journal.pone.0325563", "doiUrl": "https://doi.org/10.1371/journal.pone.0325563", "doiVerifiedAgainstCrossref": true, "pmid": "40668786", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40668786/", "pmcid": "PMC12266414", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266414/" } }, { "id": "221be65b8eeb261d", "topic": "mechanism", "quote": "For the relationship with SSB the results revealed a moderate effect for PMC (r = 0.31, p = .004; 95%-CI: 0.19 ≤ r ≤ 0.42) and a small effect for NMC (r = .25, p = .02, 95% CI:.05 ≤ r ≤ .43).", "quotedFrom": "abstract", "source": { "title": "Do metacognitions contribute to pathological health anxiety? A systematic review and meta-analysis.", "citation": "Ivan L, Foerster P, Bermpohl FMG et al.. Do metacognitions contribute to pathological health anxiety? A systematic review and meta-analysis.. PloS one, 2025.", "journal": "PloS one", "year": 2025, "studyDesign": "meta-analysis", "doi": "10.1371/journal.pone.0325563", "doiUrl": "https://doi.org/10.1371/journal.pone.0325563", "doiVerifiedAgainstCrossref": true, "pmid": "40668786", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40668786/", "pmcid": "PMC12266414", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266414/" } }, { "id": "1d3dfc8f9d4f34f9", "topic": "mechanism", "quote": "There were 36 articles (39 studies) identified by this search (N = 8984), of which 32 articles (34 studies) were included in the meta-analysis (N = 8602).", "quotedFrom": "abstract", "source": { "title": "Interpretation bias in health anxiety: a systematic review and meta-analysis.", "citation": "Du X, Witthöft M, Zhang T et al.. Interpretation bias in health anxiety: a systematic review and meta-analysis.. Psychological medicine, 2023.", "journal": "Psychological medicine", "year": 2023, "studyDesign": "meta-analysis", "doi": "10.1017/S0033291722003427", "doiUrl": "https://doi.org/10.1017/S0033291722003427", "doiVerifiedAgainstCrossref": true, "pmid": "36349699", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36349699/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "6d9b03816bc77b23", "topic": "mechanism", "quote": "Statistically equivalent effect sizes were observed for patients diagnosed with clinical health anxiety (g = 0.58) and subclinical health anxiety (g = 0.72).", "quotedFrom": "abstract", "source": { "title": "Interpretation bias in health anxiety: a systematic review and meta-analysis.", "citation": "Du X, Witthöft M, Zhang T et al.. Interpretation bias in health anxiety: a systematic review and meta-analysis.. Psychological medicine, 2023.", "journal": "Psychological medicine", "year": 2023, "studyDesign": "meta-analysis", "doi": "10.1017/S0033291722003427", "doiUrl": "https://doi.org/10.1017/S0033291722003427", "doiVerifiedAgainstCrossref": true, "pmid": "36349699", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36349699/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "6d0283b34adc0332", "topic": "mechanism", "quote": "Four databases (Web of Science, PubMed, PsycINFO, and Scopus) were searched for relevant studies, with 17 articles (N = 1546) included for a qualitative review and 16 articles (18 studies) for a three-level meta-analysis (N = 1490).", "quotedFrom": "abstract", "source": { "title": "Attentional bias toward health-threat in health anxiety: a systematic review and three-level meta-analysis.", "citation": "Shi C, Taylor S, Witthöft M et al.. Attentional bias toward health-threat in health anxiety: a systematic review and three-level meta-analysis.. Psychological medicine, 2022.", "journal": "Psychological medicine", "year": 2022, "studyDesign": "meta-analysis", "doi": "10.1017/S0033291721005432", "doiUrl": "https://doi.org/10.1017/S0033291721005432", "doiVerifiedAgainstCrossref": true, "pmid": "35341486", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/35341486/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "d2c868612618642a", "topic": "mechanism", "quote": "Additionally, compared to the controls, health-anxious individuals displayed significantly greater attention maintenance (g = 0.327) but nonsignificant attention vigilance to health-threat (g = -0.116).", "quotedFrom": "abstract", "source": { "title": "Attentional bias toward health-threat in health anxiety: a systematic review and three-level meta-analysis.", "citation": "Shi C, Taylor S, Witthöft M et al.. Attentional bias toward health-threat in health anxiety: a systematic review and three-level meta-analysis.. Psychological medicine, 2022.", "journal": "Psychological medicine", "year": 2022, "studyDesign": "meta-analysis", "doi": "10.1017/S0033291721005432", "doiUrl": "https://doi.org/10.1017/S0033291721005432", "doiVerifiedAgainstCrossref": true, "pmid": "35341486", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/35341486/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "6996a15759f93368", "topic": "mechanism", "quote": "RESULTS: Thirty-six studies (N = 12,390) met inclusion criteria with results suggesting a relatively consistent positive relationship between metacognitive beliefs and somatic distress.", "quotedFrom": "abstract", "source": { "title": "A systematic review evaluating metacognitive beliefs in health anxiety and somatic distress.", "citation": "Keen E, Kangas M, Gilchrist PT. A systematic review evaluating metacognitive beliefs in health anxiety and somatic distress.. British journal of health psychology, 2022.", "journal": "British journal of health psychology", "year": 2022, "studyDesign": "systematic-review", "doi": "10.1111/bjhp.12609", "doiUrl": "https://doi.org/10.1111/bjhp.12609", "doiVerifiedAgainstCrossref": true, "pmid": "35746856", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/35746856/", "pmcid": "PMC9796692", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9796692/" } }, { "id": "198544335171d8f4", "topic": "mechanism", "quote": "We investigated whether base-rate neglect-the cognitive bias to ignore a priori probabilities (e.g., of serious diseases)-plays a significant role in cyberchondria and health anxiety. 368 participants were randomly assigned to eight experimental conditions, manipulating the base-rate (30 % vs. 70 %), the judgment domain (health-neutral versus health-related), and the salience of base-rate information (low vs. high) in a 2×2×2 between-subjects design when asking them for probability judgments with versus without disease relevance.", "quotedFrom": "abstract", "source": { "title": "The role of base-rate neglect in cyberchondria and health anxiety.", "citation": "Nicolai J, Moshagen M, Schillings K et al.. The role of base-rate neglect in cyberchondria and health anxiety.. Journal of anxiety disorders, 2022.", "journal": "Journal of anxiety disorders", "year": 2022, "studyDesign": "rct", "doi": "10.1016/j.janxdis.2022.102609", "doiUrl": "https://doi.org/10.1016/j.janxdis.2022.102609", "doiVerifiedAgainstCrossref": true, "pmid": "35963146", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/35963146/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "b7edae74d275b268", "topic": "mechanism", "quote": "We analysed putative mediators of change based on 13 weekly assessments in a randomised controlled trial (N = 132) of exposure-based minimal-contact CBT (guided Internet-delivered CBT, unguided Internet-delivered CBT and bibliotherapy) vs. a waitlist control for severe health anxiety.", "quotedFrom": "abstract", "source": { "title": "Mediators of treatment effect in minimal-contact cognitive behaviour therapy for severe health anxiety: A theory-driven analysis based on a randomised controlled trial.", "citation": "Axelsson E, Hesser H, Andersson E et al.. Mediators of treatment effect in minimal-contact cognitive behaviour therapy for severe health anxiety: A theory-driven analysis based on a randomised controlled trial.. Journal of anxiety disorders, 2020.", "journal": "Journal of anxiety disorders", "year": 2020, "studyDesign": "rct", "doi": "10.1016/j.janxdis.2019.102172", "doiUrl": "https://doi.org/10.1016/j.janxdis.2019.102172", "doiVerifiedAgainstCrossref": true, "pmid": "31864217", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31864217/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5c59caede6022048", "topic": "mechanism", "quote": "The iCBT group showed a significantly greater reduction in cyberchondria compared to the control group, with large differences at post-treatment on the Cyberchondria Severity Scale Total scale (CSS; Hedges g = 1.09), and the Compulsion, Distress, Excessiveness subscales of the CSS (g's: 0.8-1.13).", "quotedFrom": "abstract", "source": { "title": "The impact of internet-delivered cognitive behavioural therapy for health anxiety on cyberchondria.", "citation": "Newby JM, McElroy E. The impact of internet-delivered cognitive behavioural therapy for health anxiety on cyberchondria.. Journal of anxiety disorders, 2020.", "journal": "Journal of anxiety disorders", "year": 2020, "studyDesign": "rct", "doi": "10.1016/j.janxdis.2019.102150", "doiUrl": "https://doi.org/10.1016/j.janxdis.2019.102150", "doiVerifiedAgainstCrossref": true, "pmid": "31739276", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31739276/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "27182919029be1a8", "topic": "mechanism", "quote": "Although there were no significant group differences at post-treatment or follow-up, we found small non-significant effect sizes in favour of the CBM-I Intervention group on health anxiety and cognitions (Cohen's d's between-group effect sizes of 0.28 at post-treatment and d = 0.35 at follow-up on the 18-item Short Health Anxiety Inventory).", "quotedFrom": "abstract", "source": { "title": "A randomised controlled trial of computerised interpretation bias modification for health anxiety.", "citation": "Antognelli SL, Sharrock MJ, Newby JM. A randomised controlled trial of computerised interpretation bias modification for health anxiety.. Journal of behavior therapy and experimental psychiatry, 2020.", "journal": "Journal of behavior therapy and experimental psychiatry", "year": 2020, "studyDesign": "rct", "doi": "10.1016/j.jbtep.2019.101518", "doiUrl": "https://doi.org/10.1016/j.jbtep.2019.101518", "doiVerifiedAgainstCrossref": true, "pmid": "31610436", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31610436/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "a46dcfe88ac70d0b", "topic": "mechanism", "quote": "Random effects meta-analyses showed that there was a positive correlation between health anxiety and online health information seeking [r = 0.34, 95% CI (0.20, 0.48), p < .0001], and between health anxiety and cyberchondria [r = 0.62, 95% CI (0.52, 0.71), p < .0001].", "quotedFrom": "abstract", "source": { "title": "The relationships between health anxiety, online health information seeking, and cyberchondria: Systematic review and meta-analysis.", "citation": "McMullan RD, Berle D, Arnáez S et al.. The relationships between health anxiety, online health information seeking, and cyberchondria: Systematic review and meta-analysis.. Journal of affective disorders, 2019.", "journal": "Journal of affective disorders", "year": 2019, "studyDesign": "meta-analysis", "doi": "10.1016/j.jad.2018.11.037", "doiUrl": "https://doi.org/10.1016/j.jad.2018.11.037", "doiVerifiedAgainstCrossref": true, "pmid": "30419526", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/30419526/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "7e85b41498d8ba7f", "topic": "mechanism", "quote": "A meta-regression indicated that the age of study participants [Q(1) = 4.58, p = .03] was partly responsible for the heterogeneity found for the relationship between health anxiety and cyberchondria.", "quotedFrom": "abstract", "source": { "title": "The relationships between health anxiety, online health information seeking, and cyberchondria: Systematic review and meta-analysis.", "citation": "McMullan RD, Berle D, Arnáez S et al.. The relationships between health anxiety, online health information seeking, and cyberchondria: Systematic review and meta-analysis.. Journal of affective disorders, 2019.", "journal": "Journal of affective disorders", "year": 2019, "studyDesign": "meta-analysis", "doi": "10.1016/j.jad.2018.11.037", "doiUrl": "https://doi.org/10.1016/j.jad.2018.11.037", "doiVerifiedAgainstCrossref": true, "pmid": "30419526", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/30419526/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "bea4f7bef7ec8fdc", "topic": "mechanism", "quote": "In the present study, latent process growth modeling showed that treatment condition had a significant effect on the FFMQ-NR growth trajectory (α-path), estimate=0.18, 95% CI [0.04, 0.32], p=.015, indicating a larger increase in mindful non-reactivity among participants receiving exposure-based CBT compared to the BSM group.", "quotedFrom": "abstract", "source": { "title": "The mediating effect of mindful non-reactivity in exposure-based cognitive behavior therapy for severe health anxiety.", "citation": "Hedman E, Hesser H, Andersson E et al.. The mediating effect of mindful non-reactivity in exposure-based cognitive behavior therapy for severe health anxiety.. Journal of anxiety disorders, 2017.", "journal": "Journal of anxiety disorders", "year": 2017, "studyDesign": "rct", "doi": "10.1016/j.janxdis.2017.04.007", "doiUrl": "https://doi.org/10.1016/j.janxdis.2017.04.007", "doiVerifiedAgainstCrossref": true, "pmid": "28528015", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28528015/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "605e7ce7a34dea06", "topic": "mechanism", "quote": "The FFMQ-NR growth trajectory was significantly correlated with the SHAI trajectory (β-path estimate=-1.82, 95% CI [-2.15, -1.48], p<.001.", "quotedFrom": "abstract", "source": { "title": "The mediating effect of mindful non-reactivity in exposure-based cognitive behavior therapy for severe health anxiety.", "citation": "Hedman E, Hesser H, Andersson E et al.. The mediating effect of mindful non-reactivity in exposure-based cognitive behavior therapy for severe health anxiety.. Journal of anxiety disorders, 2017.", "journal": "Journal of anxiety disorders", "year": 2017, "studyDesign": "rct", "doi": "10.1016/j.janxdis.2017.04.007", "doiUrl": "https://doi.org/10.1016/j.janxdis.2017.04.007", "doiVerifiedAgainstCrossref": true, "pmid": "28528015", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28528015/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "4af0575f90ef079f", "topic": "mechanism", "quote": "Post-treatment: Hedges's g = 0.95; Follow-up: Hedges's g = 0.34; Depression post g=0.64, follow-up g=0.35; Number of RCTs: 13; comparisons: 15; N=1,081", "quotedFrom": "abstract", "source": { "title": "Cognitive-behavioral therapy for hypochondriasis/health anxiety: a meta-analysis of treatment outcome and moderators.", "citation": "Olatunji BO et al. (2014), Behav Res Ther 58:65-74, PMID 24954212", "journal": "Behaviour research and therapy", "year": 2014, "studyDesign": "meta-analysis", "doi": "10.1016/j.brat.2014.05.002", "doiUrl": "https://doi.org/10.1016/j.brat.2014.05.002", "doiVerifiedAgainstCrossref": true, "pmid": "24954212", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24954212/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "1800f9e7c9b89ef8", "topic": "mechanism", "quote": "Results indicated that CBT outperformed control conditions on primary outcome measures at post-treatment (Hedges's g = 0.95) and at follow-up (Hedges's g = 0.34).", "quotedFrom": "abstract", "source": { "title": "Cognitive-behavioral therapy for hypochondriasis/health anxiety: a meta-analysis of treatment outcome and moderators.", "citation": "Olatunji BO, Kauffman BY, Meltzer S et al.. Cognitive-behavioral therapy for hypochondriasis/health anxiety: a meta-analysis of treatment outcome and moderators.. Behaviour research and therapy, 2014.", "journal": "Behaviour research and therapy", "year": 2014, "studyDesign": "meta-analysis", "doi": "10.1016/j.brat.2014.05.002", "doiUrl": "https://doi.org/10.1016/j.brat.2014.05.002", "doiVerifiedAgainstCrossref": true, "pmid": "24954212", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24954212/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "2649f06983e051df", "topic": "mechanism", "quote": "CBT also outperformed control conditions on measures of depression at post-treatment (Hedges's g = 0.64) and at follow-up (Hedges's g = 0.35).", "quotedFrom": "abstract", "source": { "title": "Cognitive-behavioral therapy for hypochondriasis/health anxiety: a meta-analysis of treatment outcome and moderators.", "citation": "Olatunji BO, Kauffman BY, Meltzer S et al.. Cognitive-behavioral therapy for hypochondriasis/health anxiety: a meta-analysis of treatment outcome and moderators.. Behaviour research and therapy, 2014.", "journal": "Behaviour research and therapy", "year": 2014, "studyDesign": "meta-analysis", "doi": "10.1016/j.brat.2014.05.002", "doiUrl": "https://doi.org/10.1016/j.brat.2014.05.002", "doiVerifiedAgainstCrossref": true, "pmid": "24954212", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24954212/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "6c4b10c19838b08f", "topic": "prevalence", "quote": "Participants with SSD reported more pain and post-concussion symptoms, and were more likely to have comorbid Major Depressive Disorder (OR = 9.1, 95% CI = 5.3, 16.2) and at least 1 anxiety disorder (OR = 5.6, 95% CI = 3.6-8.8) compared to those without SSD.", "quotedFrom": "abstract", "source": { "title": "Somatic Symptom Disorder After Mild Traumatic Brain Injury.", "citation": "Silverberg ND, Rioux M, Mikolić A et al.. Somatic Symptom Disorder After Mild Traumatic Brain Injury.. The Journal of head trauma rehabilitation, 2026.", "journal": "The Journal of head trauma rehabilitation", "year": 2026, "studyDesign": "other", "doi": "10.1097/HTR.0000000000001068", "doiUrl": "https://doi.org/10.1097/HTR.0000000000001068", "doiVerifiedAgainstCrossref": true, "pmid": "40384095", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40384095/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "11462b2736a05c5b", "topic": "prevalence", "quote": "Early illness beliefs, specifically that mTBI has serious life consequences (OR = 1.2, 95% CI = 1.1-1.3) and causes distress (OR = 1.1, 95% CI = 1.0-1.2), were associated with later SSD.", "quotedFrom": "abstract", "source": { "title": "Somatic Symptom Disorder After Mild Traumatic Brain Injury.", "citation": "Silverberg ND, Rioux M, Mikolić A et al.. Somatic Symptom Disorder After Mild Traumatic Brain Injury.. The Journal of head trauma rehabilitation, 2026.", "journal": "The Journal of head trauma rehabilitation", "year": 2026, "studyDesign": "other", "doi": "10.1097/HTR.0000000000001068", "doiUrl": "https://doi.org/10.1097/HTR.0000000000001068", "doiVerifiedAgainstCrossref": true, "pmid": "40384095", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40384095/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "46bf047b7166e5e1", "topic": "prevalence", "quote": "SSD was more frequent in IBS (55.0 %; 95 % CI 44.4-64.9) than in UC (29.6 %; 95 % CI 21.7-37.1) (χ2(1) = 15.67, p < .001), and linked to higher illness-related anxiety, negative illness perceptions, and symptom-related disability in both groups.", "quotedFrom": "abstract", "source": { "title": "Somatic symptom disorder in patients with irritable bowel syndrome or ulcerative colitis - Cross-sectional baseline findings from the SOMA.GUT-RCT.", "citation": "Peters L, Matysiak A, Hübener S et al.. Somatic symptom disorder in patients with irritable bowel syndrome or ulcerative colitis - Cross-sectional baseline findings from the SOMA.GUT-RCT.. Journal of psychosomatic research, 2025.", "journal": "Journal of psychosomatic research", "year": 2025, "studyDesign": "other", "doi": "10.1016/j.jpsychores.2025.112395", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2025.112395", "doiVerifiedAgainstCrossref": true, "pmid": "41045809", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41045809/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "274196ec265d8d23", "topic": "prevalence", "quote": "RESULTS: SSD was diagnosed in 41.5 % (95 % CI 35.6-47.9) out of 236 patients, including 125 patients with UC and 111 with IBS (73.7 % female; Mage = 40.14, SD = 13.8).", "quotedFrom": "abstract", "source": { "title": "Somatic symptom disorder in patients with irritable bowel syndrome or ulcerative colitis - Cross-sectional baseline findings from the SOMA.GUT-RCT.", "citation": "Peters L, Matysiak A, Hübener S et al.. Somatic symptom disorder in patients with irritable bowel syndrome or ulcerative colitis - Cross-sectional baseline findings from the SOMA.GUT-RCT.. Journal of psychosomatic research, 2025.", "journal": "Journal of psychosomatic research", "year": 2025, "studyDesign": "other", "doi": "10.1016/j.jpsychores.2025.112395", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2025.112395", "doiVerifiedAgainstCrossref": true, "pmid": "41045809", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41045809/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "ac951df9d8680658", "topic": "prevalence", "quote": "All-cause mortality: HR 1.69 (95% CI, 1.47-1.93); Natural causes: HR 1.60 (95% CI, 1.38-1.85); Unnatural causes: HR 2.43 (95% CI, 1.61-3.68); Suicide: HR 4.14 (95% CI, 2.44-7.03); Cases 4,129; Controls 41,290", "quotedFrom": "abstract", "source": { "title": "All-Cause and Cause-Specific Mortality Among Individuals With Hypochondriasis.", "citation": "Mataix-Cols D et al. (2024), JAMA Psychiatry 81(3):284-291, PMID 38091000", "journal": "JAMA psychiatry", "year": 2024, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "38091000", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/38091000/", "pmcid": "PMC10719832", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10719832/" } }, { "id": "84b625ecd9fb03a9", "topic": "prevalence", "quote": "RESULTS: There were commonalities across different conceptualizations and diseases: a high prevalence of clinical levels of fears (>20%), a stable course over time, and a deleterious impact on quality of life.", "quotedFrom": "abstract", "source": { "title": "Health anxiety and illness-related fears across diverse chronic illnesses: A systematic review on conceptualization, measurement, prevalence, course, and correlates.", "citation": "Lebel S, Mutsaers B, Tomei C et al.. Health anxiety and illness-related fears across diverse chronic illnesses: A systematic review on conceptualization, measurement, prevalence, course, and correlates.. PloS one, 2020.", "journal": "PloS one", "year": 2020, "studyDesign": "systematic-review", "doi": "10.1371/journal.pone.0234124", "doiUrl": "https://doi.org/10.1371/journal.pone.0234124", "doiVerifiedAgainstCrossref": true, "pmid": "32716932", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32716932/", "pmcid": "PMC7384626", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384626/" } }, { "id": "f5e94a8c9f509d8c", "topic": "prevalence", "quote": "The symptoms were a little more common in females (30.0%, 95% CI = 19.0%-42.0%) than in males (29.0%, 95% CI = 16.0%-42.0%), but the difference was not significant.", "quotedFrom": "abstract", "source": { "title": "Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis.", "citation": "Meng J, Gao C, Tang C et al.. Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis.. PloS one, 2019.", "journal": "PloS one", "year": 2019, "studyDesign": "meta-analysis", "doi": "10.1371/journal.pone.0222663", "doiUrl": "https://doi.org/10.1371/journal.pone.0222663", "doiVerifiedAgainstCrossref": true, "pmid": "31527902", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31527902/", "pmcid": "PMC6748570", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748570/" } }, { "id": "ecd948efacdeade7", "topic": "prevalence", "quote": "The pooled prevalence of hypochondriac symptoms among health science students was 28.0% (95% CI = 19.0%-38.0%).", "quotedFrom": "abstract", "source": { "title": "Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis.", "citation": "Meng J, Gao C, Tang C et al.. Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis.. PloS one, 2019.", "journal": "PloS one", "year": 2019, "studyDesign": "meta-analysis", "doi": "10.1371/journal.pone.0222663", "doiUrl": "https://doi.org/10.1371/journal.pone.0222663", "doiVerifiedAgainstCrossref": true, "pmid": "31527902", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31527902/", "pmcid": "PMC6748570", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748570/" } }, { "id": "6e047840ea14cf34", "topic": "prevalence", "quote": "Health anxiety affects approximately 5.7% of the Australian population across the lifespan and 3.4% met criteria for health anxiety at the time of the interview.", "quotedFrom": "abstract, Results", "source": { "title": "Health anxiety in Australia: prevalence, comorbidity, disability and service use.", "citation": "Sunderland M, Newby JM, Andrews G. Br J Psychiatry 202(1):56-61, 2013", "journal": "The British journal of psychiatry : the journal of mental science", "year": 2013, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "22500013", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/22500013/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "15a2a309e40d56ac", "topic": "prevalence", "quote": "Fully 90% of respondents with lifetime DSM-IV/CIDI OCD meet criteria for another lifetime DSM-IV/CIDI disorder.", "quotedFrom": "full text, Results (PMC2797569) — not in the abstract, which states comorbidity only qualitatively", "source": { "title": "The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication.", "citation": "Ruscio AM, Stein DJ, Chiu WT, Kessler RC. Mol Psychiatry 15(1):53-63, 2010", "journal": "Molecular psychiatry", "year": 2010, "studyDesign": "other", "doi": "10.1038/mp.2008.94", "doiUrl": "https://doi.org/10.1038/mp.2008.94", "doiVerifiedAgainstCrossref": true, "pmid": "18725912", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/18725912/", "pmcid": "PMC2797569", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797569/" } }, { "id": "742cc2003a16fe85", "topic": "prevalence", "quote": "Trait anxiety was similar for both the genders; this score was significantly below the normal Hungarian population value in women (P<0.001) and at the normal population level in men (P=0.560).", "quotedFrom": "abstract", "source": { "title": "Health anxiety in a non-population-based, pre-publicised glaucoma screening exercise.", "citation": "Holló G, Kóthy P, Géczy A et al.. Health anxiety in a non-population-based, pre-publicised glaucoma screening exercise.. Eye (London, England), 2010.", "journal": "Eye (London, England)", "year": 2010, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "19521429", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/19521429/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "d5bfafd9ac58f882", "topic": "prevalence", "quote": "In contrast, health anxiety was significantly higher than for both the 'normal' and 'anxious' reference groups (P<0.001), although smaller than that for hypochondriacs (P<0.001).", "quotedFrom": "abstract", "source": { "title": "Health anxiety in a non-population-based, pre-publicised glaucoma screening exercise.", "citation": "Holló G, Kóthy P, Géczy A et al.. Health anxiety in a non-population-based, pre-publicised glaucoma screening exercise.. Eye (London, England), 2010.", "journal": "Eye (London, England)", "year": 2010, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "19521429", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/19521429/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "0b05f819b20e7e88", "topic": "prevalence", "quote": "The current and lifetime prevalence of additional Axis I disorders in principal anxiety and mood disorders was found to be 57% and 81%, respectively.", "quotedFrom": "abstract", "source": { "title": "Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample.", "citation": "Brown TA, Campbell LA, Lehman CL, Grisham JR, Mancill RB. J Abnorm Psychol 110(4):585-599, 2001", "journal": "Journal of abnormal psychology", "year": 2001, "studyDesign": "other", "doi": "10.1037//0021-843x.110.4.585", "doiUrl": "https://doi.org/10.1037//0021-843x.110.4.585", "doiVerifiedAgainstCrossref": true, "pmid": "11727948", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/11727948/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "0507d00983589e88", "topic": "prevalence", "quote": "Hypochondriasis group: 4,129 individuals... Matched controls: 41,290 individuals... Mean of 7.7 years... All-Cause Mortality HR: 1.69 (95% CI, 1.47-1.93)... mean age of 70.0 years (SD 16.8) compared to 75.1 years (SD 15.8)... Suicide HR: 4.14 (95% CI, 2.44-7.03)... became statistically non-significant after adjustment for depressive and anxiety-related disorders... Respiratory: 2.33 (1.50-3.61)... Circulatory: 1.52 (1.21-1.92)... Cancer: 0.99 (0.74-1.33)", "quotedFrom": "full text results", "source": { "title": null, "citation": "Mataix-Cols D, et al. Association of hypochondriasis (health anxiety) with all-cause mortality and suicide. JAMA Psychiatry, 2023.", "journal": null, "year": null, "studyDesign": null, "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": null, "pubmedUrl": null, "pmcid": null, "freeFullTextUrl": null } }, { "id": "1f41aa5aa9298378", "topic": "treatment", "quote": "Post-treatment, iCBT showed no significant effect difference vs. other psychotherapies (Hedges'g [95% CI]: general symptoms = 0.09 [-0.11; 0.28]; health anxiety: = 0.18 [-0.17; 0.52]), but outperformed waitlisting across most symptoms (Hedges'g [95% CI]: general symptoms = 0.30 [0.12; 0.48]; gastrointestinal = 0.62 [0.35; 0.88]; fatigue = 0.47 [0.25; 0.68]; health anxiety = 0.71 [0.26; 1.16]).", "quotedFrom": "abstract", "source": { "title": "Efficacy of internet-based cognitive behavioral therapy on somatic symptom disorder and common related functional disorders: A meta-analysis of randomized controlled trials.", "citation": "Liu S, Li Y, He Z et al.. Efficacy of internet-based cognitive behavioral therapy on somatic symptom disorder and common related functional disorders: A meta-analysis of randomized controlled trials.. General hospital psychiatry, 2026.", "journal": "General hospital psychiatry", "year": 2026, "studyDesign": "meta-analysis", "doi": "10.1016/j.genhosppsych.2026.01.017", "doiUrl": "https://doi.org/10.1016/j.genhosppsych.2026.01.017", "doiVerifiedAgainstCrossref": true, "pmid": "41592512", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41592512/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "d9a0c9ff648e714d", "topic": "treatment", "quote": "The effect of iCBT was not significantly different or slightly higher than treatment as usual after treatment (Hedges'g [95% CI]: gastrointestinal = 0.41 [0.23; 0.58]; fatigue = 0.65 [-0.51; 1.82]; fibromyalgia = 0.27 [0.00; 0.55]).", "quotedFrom": "abstract", "source": { "title": "Efficacy of internet-based cognitive behavioral therapy on somatic symptom disorder and common related functional disorders: A meta-analysis of randomized controlled trials.", "citation": "Liu S, Li Y, He Z et al.. Efficacy of internet-based cognitive behavioral therapy on somatic symptom disorder and common related functional disorders: A meta-analysis of randomized controlled trials.. General hospital psychiatry, 2026.", "journal": "General hospital psychiatry", "year": 2026, "studyDesign": "meta-analysis", "doi": "10.1016/j.genhosppsych.2026.01.017", "doiUrl": "https://doi.org/10.1016/j.genhosppsych.2026.01.017", "doiVerifiedAgainstCrossref": true, "pmid": "41592512", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41592512/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "2b1bd07af7393499", "topic": "treatment", "quote": "Ten cross-sectional case-controls studies in patients with SSD and controls (12 publications, N = 314) were found eligible for our review, out of which nine studies were included in our meta-analysis.", "quotedFrom": "abstract", "source": { "title": "Mentalizing impairments in somatic symptom disorder: a systematic review and meta-analysis.", "citation": "Kocsis-Bogar K, Deri J, Miklósi M et al.. Mentalizing impairments in somatic symptom disorder: a systematic review and meta-analysis.. Frontiers in psychology, 2026.", "journal": "Frontiers in psychology", "year": 2026, "studyDesign": "systematic-review", "doi": "10.3389/fpsyg.2026.1704193", "doiUrl": "https://doi.org/10.3389/fpsyg.2026.1704193", "doiVerifiedAgainstCrossref": true, "pmid": "41768187", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41768187/", "pmcid": "PMC12947387", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947387/" } }, { "id": "48ea0b074a9db1d1", "topic": "treatment", "quote": "SSD patients demonstrated significant impairments in mentalizing in general as well as in mentalizing about cognitive and affective states (p = 0.001) compared to non-clinical controls.", "quotedFrom": "abstract", "source": { "title": "Mentalizing impairments in somatic symptom disorder: a systematic review and meta-analysis.", "citation": "Kocsis-Bogar K, Deri J, Miklósi M et al.. Mentalizing impairments in somatic symptom disorder: a systematic review and meta-analysis.. Frontiers in psychology, 2026.", "journal": "Frontiers in psychology", "year": 2026, "studyDesign": "systematic-review", "doi": "10.3389/fpsyg.2026.1704193", "doiUrl": "https://doi.org/10.3389/fpsyg.2026.1704193", "doiVerifiedAgainstCrossref": true, "pmid": "41768187", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41768187/", "pmcid": "PMC12947387", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947387/" } }, { "id": "66e214077cc5d37b", "topic": "treatment", "quote": "RESULTS: The effect of CBT-txt-A on reducing GAD symptoms was significantly stronger for residents of more rural, than urban, regions (β = -1.949, p = .023, 95% confidence interval = -3.627, -0.271), with the treatment effect size approximately three times larger in more rural, than more urban, regions.", "quotedFrom": "abstract", "source": { "title": "Urban-Rural Variation in the Efficacy of a Mobile Health Anxiety Treatment for Young Adults: Secondary Analysis of a Randomized Clinical Trial.", "citation": "Mennis J, Coatsworth JD, Brown A et al.. Urban-Rural Variation in the Efficacy of a Mobile Health Anxiety Treatment for Young Adults: Secondary Analysis of a Randomized Clinical Trial.. The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2026.", "journal": "The Journal of adolescent health : official publication of the Society for Adolescent Medicine", "year": 2026, "studyDesign": "rct", "doi": "10.1016/j.jadohealth.2026.02.008", "doiUrl": "https://doi.org/10.1016/j.jadohealth.2026.02.008", "doiVerifiedAgainstCrossref": true, "pmid": "41830951", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41830951/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "17193089a78b3b9c", "topic": "treatment", "quote": "SSD frequency was 42.3% (95% CI: 35.2-49.3) at baseline and 15.5% (95% CI, 11.3-20.7) at follow-up.", "quotedFrom": "abstract", "source": { "title": "Course and predictors of somatic symptom disorder in irritable bowel syndrome and ulcerative colitis: A longitudinal analysis from the SOMA.GUT-RCT.", "citation": "Peters L, Matysiak A, Hübener S et al.. Course and predictors of somatic symptom disorder in irritable bowel syndrome and ulcerative colitis: A longitudinal analysis from the SOMA.GUT-RCT.. General hospital psychiatry, 2026.", "journal": "General hospital psychiatry", "year": 2026, "studyDesign": "rct", "doi": "10.1016/j.genhosppsych.2026.03.004", "doiUrl": "https://doi.org/10.1016/j.genhosppsych.2026.03.004", "doiVerifiedAgainstCrossref": true, "pmid": "41833154", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41833154/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "97f7dab2025fed0a", "topic": "treatment", "quote": "RESULTS: The sample included 213 patients (73.7% female; Mage = 40.5, SD = 13.98) with UC (n = 110) or IBS (n = 103).", "quotedFrom": "abstract", "source": { "title": "Course and predictors of somatic symptom disorder in irritable bowel syndrome and ulcerative colitis: A longitudinal analysis from the SOMA.GUT-RCT.", "citation": "Peters L, Matysiak A, Hübener S et al.. Course and predictors of somatic symptom disorder in irritable bowel syndrome and ulcerative colitis: A longitudinal analysis from the SOMA.GUT-RCT.. General hospital psychiatry, 2026.", "journal": "General hospital psychiatry", "year": 2026, "studyDesign": "rct", "doi": "10.1016/j.genhosppsych.2026.03.004", "doiUrl": "https://doi.org/10.1016/j.genhosppsych.2026.03.004", "doiVerifiedAgainstCrossref": true, "pmid": "41833154", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41833154/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "22e028f2a9094ae4", "topic": "treatment", "quote": "Privacy concerns were significantly associated with the education level of participant's spouse, participant's age, FPQ total scores, and referral by a health professional (p < 0.001).", "quotedFrom": "abstract", "source": { "title": "Privacy concerns, fear of pain, and health anxiety in women participating in cervical cancer screening: A cross-sectional study.", "citation": "Yılmaz H, Erkal Aksoy Y. Privacy concerns, fear of pain, and health anxiety in women participating in cervical cancer screening: A cross-sectional study.. Health care for women international, 2026.", "journal": "Health care for women international", "year": 2026, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "42372105", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42372105/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "aaa254f3f16e73cd", "topic": "treatment", "quote": "Higher FoP scores were also significantly associated with higher HA (p < 0.001).", "quotedFrom": "abstract", "source": { "title": "Privacy concerns, fear of pain, and health anxiety in women participating in cervical cancer screening: A cross-sectional study.", "citation": "Yılmaz H, Erkal Aksoy Y. Privacy concerns, fear of pain, and health anxiety in women participating in cervical cancer screening: A cross-sectional study.. Health care for women international, 2026.", "journal": "Health care for women international", "year": 2026, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "42372105", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42372105/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5092a2f38644b22a", "topic": "treatment", "quote": "Regression analysis indicated that the duration of employment in the current hospital and attitudes towards cancer screenings significantly predicted health anxiety (F = 8.0, p < 0.001), explaining 15.1% of the variance.", "quotedFrom": "abstract", "source": { "title": "Assessment of Nurses' Health Anxiety and Attitudes Towards Cancer Screenings: A Cross-Sectional and Analytical Study.", "citation": "Yıldırım D, Bahar Z, Coşkun Z et al.. Assessment of Nurses' Health Anxiety and Attitudes Towards Cancer Screenings: A Cross-Sectional and Analytical Study.. International journal of nursing practice, 2026.", "journal": "International journal of nursing practice", "year": 2026, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "42359601", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42359601/", "pmcid": "PMC13306534", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13306534/" } }, { "id": "39b4f0a65271462d", "topic": "treatment", "quote": "A total of 1755 women participated, with a cervical cancer screening rate of 56.2%.", "quotedFrom": "abstract", "source": { "title": "Factors influencing the decision to undergo cervical cancer screening tests (Pap Smear and HPV-DNA testing) in women aged 30-65: The role of HPV knowledge, cancer screening perception, health anxiety, and behaviors for protection against sexually transmitted diseases.", "citation": "Aslan B, Önal Ö. Factors influencing the decision to undergo cervical cancer screening tests (Pap Smear and HPV-DNA testing) in women aged 30-65: The role of HPV knowledge, cancer screening perception, health anxiety, and behaviors for protection against sexually transmitted diseases.. Journal of health psychology, 2026.", "journal": "Journal of health psychology", "year": 2026, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "41044882", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41044882/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "bf6c384ff557ea4c", "topic": "treatment", "quote": "The pooled mean difference in change of numeric rating scale (NRS) score was not statistically significant between acupuncture plus duloxetine group and duloxetine alone group at week 2 (-1.25, 95%CI: -3.03 to 0.53; p = 0.17), 4 (-0.96; 95%CI: -2.30 to 0.38; p = 0.16), and 6/8 (-1.27, 95%CI: -3.81 to 1.26; p = 0.33) from baseline.", "quotedFrom": "abstract", "source": { "title": "Effect of acupuncture on somatic symptom disorder: a systematic review and meta-analysis.", "citation": "Zhao F, Wang W, Feng X et al.. Effect of acupuncture on somatic symptom disorder: a systematic review and meta-analysis.. Frontiers in medicine, 2025.", "journal": "Frontiers in medicine", "year": 2025, "studyDesign": "systematic-review", "doi": "10.3389/fmed.2025.1625230", "doiUrl": "https://doi.org/10.3389/fmed.2025.1625230", "doiVerifiedAgainstCrossref": true, "pmid": "41103694", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41103694/", "pmcid": "PMC12521258", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521258/" } }, { "id": "9e3eb06a266fe2d6", "topic": "treatment", "quote": "Four of the studies showed the pooled estimates of mean difference in the change of HAMA scores between acupuncture plus paroxetine or duloxetine group and medication alone group were statistically significant at week 4 (-1.94, 95%CI: -3.71 to -0.17; p = 0.03) with borderline significance at week 6/8 (-3.17, 95%CI: -6.38 to 0.04; p = 0.05) from baseline.", "quotedFrom": "abstract", "source": { "title": "Effect of acupuncture on somatic symptom disorder: a systematic review and meta-analysis.", "citation": "Zhao F, Wang W, Feng X et al.. Effect of acupuncture on somatic symptom disorder: a systematic review and meta-analysis.. Frontiers in medicine, 2025.", "journal": "Frontiers in medicine", "year": 2025, "studyDesign": "systematic-review", "doi": "10.3389/fmed.2025.1625230", "doiUrl": "https://doi.org/10.3389/fmed.2025.1625230", "doiVerifiedAgainstCrossref": true, "pmid": "41103694", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41103694/", "pmcid": "PMC12521258", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521258/" } }, { "id": "8ceaa0cb1c62829a", "topic": "treatment", "quote": "N = 261 participants (age: M = 27.79, SD = 9.61; sex: 77.8% females, 21.5% males, 0.8% divers) were randomly assigned to 4 conditions, manipulating priors on somatic symptom probability (symptom-prior: precise and high probability vs precise and low probability) and origins of somatic symptoms (hidden-state-prior: imprecise vs precise and nonillness).", "quotedFrom": "abstract", "source": { "title": "Support for Predictive Processing Assumptions on Health Anxiety: Imprecise Expectations on the Origin of Somatic Symptoms Increase Health Anxiety.", "citation": "Sauer KS, Pohl A, Van den Bergh O et al.. Support for Predictive Processing Assumptions on Health Anxiety: Imprecise Expectations on the Origin of Somatic Symptoms Increase Health Anxiety.. Biopsychosocial science and medicine, 2025.", "journal": "Biopsychosocial science and medicine", "year": 2025, "studyDesign": "rct", "doi": "10.1097/PSY.0000000000001437", "doiUrl": "https://doi.org/10.1097/PSY.0000000000001437", "doiVerifiedAgainstCrossref": true, "pmid": "40964919", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40964919/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "106e907170e2744d", "topic": "treatment", "quote": "RESULTS: We did not observe any significant effects of symptom-prior manipulation on symptom report ( p = .27).", "quotedFrom": "abstract", "source": { "title": "Support for Predictive Processing Assumptions on Health Anxiety: Imprecise Expectations on the Origin of Somatic Symptoms Increase Health Anxiety.", "citation": "Sauer KS, Pohl A, Van den Bergh O et al.. Support for Predictive Processing Assumptions on Health Anxiety: Imprecise Expectations on the Origin of Somatic Symptoms Increase Health Anxiety.. Biopsychosocial science and medicine, 2025.", "journal": "Biopsychosocial science and medicine", "year": 2025, "studyDesign": "rct", "doi": "10.1097/PSY.0000000000001437", "doiUrl": "https://doi.org/10.1097/PSY.0000000000001437", "doiVerifiedAgainstCrossref": true, "pmid": "40964919", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40964919/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "8d10e26c075b9f39", "topic": "treatment", "quote": "Participants with elevated health anxiety (N = 106) were recruited from across the United States and randomized to receive one of two 1-month text message interventions, which included reminders to avoid use of health-related safety behaviors (SB) or to focus on the present (PC).", "quotedFrom": "abstract", "source": { "title": "Effects of text message reminders of safety behavior reduction on health anxiety: A randomized control trial.", "citation": "Jakes KS, Jessup SC, Rosenfield D et al.. Effects of text message reminders of safety behavior reduction on health anxiety: A randomized control trial.. Behaviour research and therapy, 2025.", "journal": "Behaviour research and therapy", "year": 2025, "studyDesign": "rct", "doi": "10.1016/j.brat.2025.104790", "doiUrl": "https://doi.org/10.1016/j.brat.2025.104790", "doiVerifiedAgainstCrossref": true, "pmid": "40494257", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40494257/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "1ef48f0f17eba3a6", "topic": "treatment", "quote": "Three-level meta-analytic results showed a weighted average dropout rate of 9.67% (95% confidence interval [CI] [6.49%, 14.17%]), with dropout equally likely from treatment and control conditions (odds ratio = 1.07, 95% CI [0.80, 1.44]).", "quotedFrom": "abstract", "source": { "title": "Dropout From Psychological Interventions for Pathological Health Anxiety: A Three-Level Meta-Analysis of Randomized Controlled Trials.", "citation": "Shi C, Wu Y, Wei H et al.. Dropout From Psychological Interventions for Pathological Health Anxiety: A Three-Level Meta-Analysis of Randomized Controlled Trials.. Clinical psychology & psychotherapy, 2024.", "journal": "Clinical psychology & psychotherapy", "year": 2024, "studyDesign": "meta-analysis", "doi": "10.1002/cpp.3064", "doiUrl": "https://doi.org/10.1002/cpp.3064", "doiVerifiedAgainstCrossref": true, "pmid": "39363535", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/39363535/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5ad59a93878fd935", "topic": "treatment", "quote": "RESULTS: Forty-three eligible studies (n = 3760 patients) in SSD (none in BDD) provided data on at least one psychological factor, 37 in case-control format, 10 cross-sectional and 5 longitudinal.", "quotedFrom": "abstract", "source": { "title": "Psychological risk factors of somatic symptom disorder: A systematic review and meta-analysis of cross-sectional and longitudinal studies.", "citation": "Smakowski A, Hüsing P, Völcker S et al.. Psychological risk factors of somatic symptom disorder: A systematic review and meta-analysis of cross-sectional and longitudinal studies.. Journal of psychosomatic research, 2024.", "journal": "Journal of psychosomatic research", "year": 2024, "studyDesign": "meta-analysis", "doi": "10.1016/j.jpsychores.2024.111608", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2024.111608", "doiVerifiedAgainstCrossref": true, "pmid": "38365462", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/38365462/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "c5a829daa068a93c", "topic": "treatment", "quote": "The results showed that internet-based psychological interventions had a moderate to large between-group effect on health anxiety (g = 0.70) that was significant both at post-intervention (g = 0.74) and follow-up (g = 0.64).", "quotedFrom": "abstract", "source": { "title": "Efficacy of internet-based psychological interventions for pathological health anxiety: A three-level meta-analysis of randomized controlled trials.", "citation": "Shi C, Zhang T, Du X et al.. Efficacy of internet-based psychological interventions for pathological health anxiety: A three-level meta-analysis of randomized controlled trials.. General hospital psychiatry, 2024.", "journal": "General hospital psychiatry", "year": 2024, "studyDesign": "meta-analysis", "doi": "10.1016/j.genhosppsych.2024.02.001", "doiUrl": "https://doi.org/10.1016/j.genhosppsych.2024.02.001", "doiVerifiedAgainstCrossref": true, "pmid": "38335917", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/38335917/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "cf127e7236a3d951", "topic": "treatment", "quote": "Furthermore, these interventions were significantly more effective than passive control conditions including waitlist, usual care, and placebo at post-treatment (g = 1.07), but had effects comparable to active control groups at both post-intervention and follow-up.", "quotedFrom": "abstract", "source": { "title": "Efficacy of internet-based psychological interventions for pathological health anxiety: A three-level meta-analysis of randomized controlled trials.", "citation": "Shi C, Zhang T, Du X et al.. Efficacy of internet-based psychological interventions for pathological health anxiety: A three-level meta-analysis of randomized controlled trials.. General hospital psychiatry, 2024.", "journal": "General hospital psychiatry", "year": 2024, "studyDesign": "meta-analysis", "doi": "10.1016/j.genhosppsych.2024.02.001", "doiUrl": "https://doi.org/10.1016/j.genhosppsych.2024.02.001", "doiVerifiedAgainstCrossref": true, "pmid": "38335917", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/38335917/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "bd73710bb77f28d7", "topic": "treatment", "quote": "The random-effects meta-analysis revealed a significant positive correlation between online health information seeking and health anxiety (r = 0.28, 95% confidence interval [0.16, 0.41], p < .0001), despite considerable heterogeneity.", "quotedFrom": "abstract", "source": { "title": "Is There a Relationship Between Online Health Information Seeking and Health Anxiety? A Systematic Review and Meta-Analysis.", "citation": "Wang Z, Hu Y, Huang B et al.. Is There a Relationship Between Online Health Information Seeking and Health Anxiety? A Systematic Review and Meta-Analysis.. Health communication, 2024.", "journal": "Health communication", "year": 2024, "studyDesign": "meta-analysis", "doi": "10.1080/10410236.2023.2275921", "doiUrl": "https://doi.org/10.1080/10410236.2023.2275921", "doiVerifiedAgainstCrossref": true, "pmid": "37919837", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37919837/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "440516b1929bcfb2", "topic": "treatment", "quote": "SSDs exhibited a lower level of adaptive ER (overall Hedge's g = -0.618, 95 %CI [0.872, -0.365]; Hedge's g for ER dimensions of Awareness, Description, Clarity, Acceptance, Tolerance, Self-efficacy belief, and Cognitive Reappraisal ranged from -0.451 to -1.344).", "quotedFrom": "abstract", "source": { "title": "The association between emotional regulation dimensions and somatic symptom disorders: A systematic review and meta-analysis.", "citation": "Yan H, Zhou A, Li Q et al.. The association between emotional regulation dimensions and somatic symptom disorders: A systematic review and meta-analysis.. Asian journal of psychiatry, 2024.", "journal": "Asian journal of psychiatry", "year": 2024, "studyDesign": "meta-analysis", "doi": "10.1016/j.ajp.2024.104151", "doiUrl": "https://doi.org/10.1016/j.ajp.2024.104151", "doiVerifiedAgainstCrossref": true, "pmid": "39018700", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/39018700/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5647655a498998ec", "topic": "treatment", "quote": "The duration of the active and latent phase of labor was significantly lower and the weight of newborn was significantly higher in the intervention group than the control group (P < 0.05).", "quotedFrom": "abstract", "source": { "title": "The effect of prenatal education on health anxiety of primigravid women.", "citation": "Nikoozad S, Safdari-Dehcheshmeh F, Sharifi F et al.. The effect of prenatal education on health anxiety of primigravid women.. BMC pregnancy and childbirth, 2024.", "journal": "BMC pregnancy and childbirth", "year": 2024, "studyDesign": "rct", "doi": "10.1186/s12884-024-06718-2", "doiUrl": "https://doi.org/10.1186/s12884-024-06718-2", "doiVerifiedAgainstCrossref": true, "pmid": "39143475", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/39143475/", "pmcid": "PMC11325567", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325567/" } }, { "id": "798b2a496e07070e", "topic": "treatment", "quote": "RESULTS: It has been determined that the PCS total mean score after the intervention is 58.91 ± 7.18 in the experimental group and 50.56 ± 15.78 in the control group; the post-test FHAI total mean score is 4.52 ± 1.66 in the experimental group and 9.76 ± 5.00 in the control group, and the difference between the groups is statistically significant (p < 0.001).", "quotedFrom": "abstract", "source": { "title": "The Effects of MBSR Programme on Prenatal Comfort and Fetal Health Anxiety in Pregnant Women.", "citation": "İbici Akca E, Gökbulut N, Cengizhan SO. The Effects of MBSR Programme on Prenatal Comfort and Fetal Health Anxiety in Pregnant Women.. Journal of reproductive and infant psychology, 2024.", "journal": "Journal of reproductive and infant psychology", "year": 2024, "studyDesign": "rct", "doi": "10.1080/02646838.2023.2227219", "doiUrl": "https://doi.org/10.1080/02646838.2023.2227219", "doiVerifiedAgainstCrossref": true, "pmid": "37342975", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37342975/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "886eab68ccca907a", "topic": "treatment", "quote": "Between-group differences were large at 8 weeks (Cohen's d = 0.94) and increased by end of treatment (Cohen's d = 1.54).", "quotedFrom": "abstract", "source": { "title": "Halifax somatic symptom disorder trial: A pilot randomized controlled trial of intensive short-term dynamic psychotherapy in the emergency department.", "citation": "Town JM, Abbass A, Campbell S. Halifax somatic symptom disorder trial: A pilot randomized controlled trial of intensive short-term dynamic psychotherapy in the emergency department.. Journal of psychosomatic research, 2024.", "journal": "Journal of psychosomatic research", "year": 2024, "studyDesign": "rct", "doi": "10.1016/j.jpsychores.2024.111889", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2024.111889", "doiVerifiedAgainstCrossref": true, "pmid": "39241562", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/39241562/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "a53b27c17b163267", "topic": "treatment", "quote": "RESULTS: Recruitment was efficient reflected in an overall recruitment yield (number randomized per number screened) of 55% (51/92) and a consent rate (number randomized per number eligible) of 94% (51/54).", "quotedFrom": "abstract", "source": { "title": "An integrated mental health video consultations model for patients with somatic symptom disorder in primary care: The randomized VISION pilot trial.", "citation": "Haun MW, van Eickels D, Tönnies J et al.. An integrated mental health video consultations model for patients with somatic symptom disorder in primary care: The randomized VISION pilot trial.. Journal of psychosomatic research, 2024.", "journal": "Journal of psychosomatic research", "year": 2024, "studyDesign": "rct", "doi": "10.1016/j.jpsychores.2024.111801", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2024.111801", "doiVerifiedAgainstCrossref": true, "pmid": "38761536", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/38761536/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "ae188314a2d18fc4", "topic": "treatment", "quote": "Acceptability of the intervention was high with 98% (123/125) of the video consultations conducted as planned.", "quotedFrom": "abstract", "source": { "title": "An integrated mental health video consultations model for patients with somatic symptom disorder in primary care: The randomized VISION pilot trial.", "citation": "Haun MW, van Eickels D, Tönnies J et al.. An integrated mental health video consultations model for patients with somatic symptom disorder in primary care: The randomized VISION pilot trial.. Journal of psychosomatic research, 2024.", "journal": "Journal of psychosomatic research", "year": 2024, "studyDesign": "rct", "doi": "10.1016/j.jpsychores.2024.111801", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2024.111801", "doiVerifiedAgainstCrossref": true, "pmid": "38761536", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/38761536/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "dbadee99b892d341", "topic": "treatment", "quote": "Regarding the primary outcome measures for health anxiety, response rates were 51%-63%, and remission rates were 29%-43%.", "quotedFrom": "abstract, Results", "source": { "title": "Exposure therapy for health anxiety: Effectiveness and response rates in routine care of an outpatient clinic.", "citation": "Roth-Rawald J, Maass U, Mai S, Weck F. J Clin Psychol 79(12):2884-2898, 2023", "journal": "Journal of clinical psychology", "year": 2023, "studyDesign": "other", "doi": "10.1002/jclp.23587", "doiUrl": "https://doi.org/10.1002/jclp.23587", "doiVerifiedAgainstCrossref": true, "pmid": "37597253", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37597253/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "ba1ef17e082b7ebe", "topic": "treatment", "quote": "health anxiety symptoms decreased significantly both posttreatment (Cohen's d = 0.97-1.00) and at follow-up (Cohen's d = 1.33-1.34)", "quotedFrom": "abstract, Results", "source": { "title": "Exposure therapy for health anxiety: Effectiveness and response rates in routine care of an outpatient clinic.", "citation": "Roth-Rawald J, et al. J Clin Psychol, 2023", "journal": "Journal of clinical psychology", "year": 2023, "studyDesign": "other", "doi": "10.1002/jclp.23587", "doiUrl": "https://doi.org/10.1002/jclp.23587", "doiVerifiedAgainstCrossref": true, "pmid": "37597253", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37597253/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "2bdf6bf057ae21d1", "topic": "treatment", "quote": "In the original investigation, 17% reported at least one adverse event, 0-10% met criteria for overall symptom deterioration, and 10-19% dropped out.", "quotedFrom": "abstract", "source": { "title": "Unwanted outcomes in cognitive behavior therapy for pathological health anxiety: a systematic review and a secondary original study of two randomized controlled trials.", "citation": "Axelsson E, Hedman-Lagerlöf E. Unwanted outcomes in cognitive behavior therapy for pathological health anxiety: a systematic review and a secondary original study of two randomized controlled trials.. Expert review of pharmacoeconomics & outcomes research, 2023.", "journal": "Expert review of pharmacoeconomics & outcomes research", "year": 2023, "studyDesign": "systematic-review", "doi": "10.1080/14737167.2023.2250915", "doiUrl": "https://doi.org/10.1080/14737167.2023.2250915", "doiVerifiedAgainstCrossref": true, "pmid": "37614181", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37614181/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "3f1b5840be4c7b48", "topic": "treatment", "quote": "AREAS COVERED: We investigated unwanted outcomes in the form of adverse events, overall symptom deterioration, and dropouts in CBT for pathological health anxiety based on a systematic review of 19 randomized controlled trials (PubMed, PsycInfo, and OATD; last updated 2 June 2023; pooled N = 2188), and then a secondary original study of two randomized controlled trials (pooled N = 336).", "quotedFrom": "abstract", "source": { "title": "Unwanted outcomes in cognitive behavior therapy for pathological health anxiety: a systematic review and a secondary original study of two randomized controlled trials.", "citation": "Axelsson E, Hedman-Lagerlöf E. Unwanted outcomes in cognitive behavior therapy for pathological health anxiety: a systematic review and a secondary original study of two randomized controlled trials.. Expert review of pharmacoeconomics & outcomes research, 2023.", "journal": "Expert review of pharmacoeconomics & outcomes research", "year": 2023, "studyDesign": "systematic-review", "doi": "10.1080/14737167.2023.2250915", "doiUrl": "https://doi.org/10.1080/14737167.2023.2250915", "doiVerifiedAgainstCrossref": true, "pmid": "37614181", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37614181/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "96904e09ffb54f34", "topic": "treatment", "quote": "Also, the intervention group compared to the control group had better QOL after the intervention in general health perceptions (3.03±0.96 vs. 2.43±0.95, P=0.01), mental health (7.12±2.25 vs. 6.34±1.85 and P=0.01) and mental component summary) 16.78±3.75 vs. 15.43±3.05, P=0.01), physical component summary (16.06±2.66 vs. 15.19±2.25, P=0.01), and total score of SF-12 (32.84±5.39 vs. 30.62±4.34, P=0.004).", "quotedFrom": "abstract", "source": { "title": "The Effect of Internet-delivered Mindfulness Stress Reduction Combined with Acceptance and Commitment Therapy on Health Anxiety and Quality of Life of Caregiver of Patients Infected by COVID-19: A Randomized Clinical Trial.", "citation": "Shahidi S, Zargar F, Aghaee Khajelangi H et al.. The Effect of Internet-delivered Mindfulness Stress Reduction Combined with Acceptance and Commitment Therapy on Health Anxiety and Quality of Life of Caregiver of Patients Infected by COVID-19: A Randomized Clinical Trial.. International journal of community based nursing and midwifery, 2023.", "journal": "International journal of community based nursing and midwifery", "year": 2023, "studyDesign": "rct", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "37114098", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37114098/", "pmcid": "PMC10126443", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126443/" } }, { "id": "cd8fe33aeb1ddf6e", "topic": "treatment", "quote": "RESULTS: The results showed that the intervention group compared to the control group had a significant decrease in all subscales of HAI after the intervention including worry about consequences (5.78±2.66 vs. 7.37±1.34, P=0.004) and awareness of bodily sensation or changes (8.90±2.77 vs. 11.75±2.30, P=0.001), worry about health (10.94±2.38 vs. 13.09±1.92, P=0.001), and total score of HAI (25.62±4.93 vs. 32.25±3.93, P=0.001).", "quotedFrom": "abstract", "source": { "title": "The Effect of Internet-delivered Mindfulness Stress Reduction Combined with Acceptance and Commitment Therapy on Health Anxiety and Quality of Life of Caregiver of Patients Infected by COVID-19: A Randomized Clinical Trial.", "citation": "Shahidi S, Zargar F, Aghaee Khajelangi H et al.. The Effect of Internet-delivered Mindfulness Stress Reduction Combined with Acceptance and Commitment Therapy on Health Anxiety and Quality of Life of Caregiver of Patients Infected by COVID-19: A Randomized Clinical Trial.. International journal of community based nursing and midwifery, 2023.", "journal": "International journal of community based nursing and midwifery", "year": 2023, "studyDesign": "rct", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "37114098", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37114098/", "pmcid": "PMC10126443", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126443/" } }, { "id": "c39dab944f6079b6", "topic": "treatment", "quote": "By the end of 8th week, the level of health anxiety (MD=11.34, P < 0.001) of the experiment group was significantly lower than the control group, while the level of acceptance of disability (MD=91.42, P < 0.001) of experiment group was significantly higher than the control group.", "quotedFrom": "abstract", "source": { "title": "A smartphone-based supportive counseling on health anxiety and acceptance of disability in Systemic Lupus Erythematosus patients: A randomized clinical trial.", "citation": "Pasyar N, Sam A, Rivaz M et al.. A smartphone-based supportive counseling on health anxiety and acceptance of disability in Systemic Lupus Erythematosus patients: A randomized clinical trial.. Patient education and counseling, 2023.", "journal": "Patient education and counseling", "year": 2023, "studyDesign": "rct", "doi": "10.1016/j.pec.2023.107676", "doiUrl": "https://doi.org/10.1016/j.pec.2023.107676", "doiVerifiedAgainstCrossref": true, "pmid": "36841083", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36841083/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "9ef679e4e8ea0dac", "topic": "treatment", "quote": "RESULTS: The findings indicated that patients who received CBT got a significant reduction in their diabetes distress F(1,60) = 222.710, P < 0.001, η2 = .788), depressive symptoms F(1,60) = 94.436, P < 0.001, η2 = .611), health anxiety F(1,60) = 201.915, P < .0.001, η2 = 771), and a significant improvement in their quality of life F(1,60) = 83.352, P < 0.001, η2 = .581), treatment adherence F(1,60) = 67.579, P < 0.001, η2 = .566) and physical activity schedule F(1,60) = 164.245, P < .0.001, η2 = .736 as compared to the patients in waitlist control condition.", "quotedFrom": "abstract", "source": { "title": "Cognitive behavior therapy for diabetes distress, depression, health anxiety, quality of life and treatment adherence among patients with type-II diabetes mellitus: a randomized control trial.", "citation": "Abbas Q, Latif S, Ayaz Habib H et al.. Cognitive behavior therapy for diabetes distress, depression, health anxiety, quality of life and treatment adherence among patients with type-II diabetes mellitus: a randomized control trial.. BMC psychiatry, 2023.", "journal": "BMC psychiatry", "year": 2023, "studyDesign": "rct", "doi": "10.1186/s12888-023-04546-w", "doiUrl": "https://doi.org/10.1186/s12888-023-04546-w", "doiVerifiedAgainstCrossref": true, "pmid": "36737757", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36737757/", "pmcid": "PMC9896442", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896442/" } }, { "id": "b326813ce914e47a", "topic": "treatment", "quote": "Ninety patients met the eligibility criteria and were randomly assigned to experimental (n = 45) and waitlist control (n = 45) conditions.", "quotedFrom": "abstract", "source": { "title": "Cognitive behavior therapy for diabetes distress, depression, health anxiety, quality of life and treatment adherence among patients with type-II diabetes mellitus: a randomized control trial.", "citation": "Abbas Q, Latif S, Ayaz Habib H et al.. Cognitive behavior therapy for diabetes distress, depression, health anxiety, quality of life and treatment adherence among patients with type-II diabetes mellitus: a randomized control trial.. BMC psychiatry, 2023.", "journal": "BMC psychiatry", "year": 2023, "studyDesign": "rct", "doi": "10.1186/s12888-023-04546-w", "doiUrl": "https://doi.org/10.1186/s12888-023-04546-w", "doiVerifiedAgainstCrossref": true, "pmid": "36737757", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36737757/", "pmcid": "PMC9896442", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896442/" } }, { "id": "7618a01f97005529", "topic": "treatment", "quote": "Standard Deviation of the NN Interval and psychological symptoms improved significantly more strongly in the HRV-BF than in the AT group (e.g., Standard Deviation of the NN Interval: ηp2 interaction = 0.10, p = .047).", "quotedFrom": "abstract", "source": { "title": "Efficacy of Heart Rate Variability Biofeedback for Somatic Symptom Disorder: A Pilot Randomized Controlled Trial.", "citation": "Krempel L, Martin A. Efficacy of Heart Rate Variability Biofeedback for Somatic Symptom Disorder: A Pilot Randomized Controlled Trial.. Psychosomatic medicine, 2023.", "journal": "Psychosomatic medicine", "year": 2023, "studyDesign": "rct", "doi": "10.1097/PSY.0000000000001143", "doiUrl": "https://doi.org/10.1097/PSY.0000000000001143", "doiVerifiedAgainstCrossref": true, "pmid": "36201761", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36201761/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5839913f79c19804", "topic": "treatment", "quote": "CBT vs. Wait-list Control: g = -1.32 [95% CI -1.75 to -0.90], k=7, I²=0%", "quotedFrom": "abstract", "source": { "title": "Meta-analysis of cognitive behaviour therapy and selective serotonin reuptake inhibitors for the treatment of hypochondriasis: Implications for trial design.", "citation": "Fineberg NA et al. (2022), Compr Psychiatry 118:152334, PMID 36007340", "journal": "Comprehensive psychiatry", "year": 2022, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "36007340", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36007340/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "ab131fa80e173dfc", "topic": "treatment", "quote": "CBT vs. Psychological or Pharmacological Placebo: g = -0.58 [95% CI -0.95 to -0.22], k=7, I²=82%", "quotedFrom": "abstract", "source": { "title": "Meta-analysis of cognitive behaviour therapy and selective serotonin reuptake inhibitors for the treatment of hypochondriasis: Implications for trial design.", "citation": "Fineberg NA et al. (2022), Compr Psychiatry 118:152334, PMID 36007340", "journal": "Comprehensive psychiatry", "year": 2022, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "36007340", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36007340/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "b268b83578723849", "topic": "treatment", "quote": "Unadjusted: g = -0.70 [95% CI -0.99 to -0.41], k = 18, I² = 81.1%", "quotedFrom": "abstract", "source": { "title": "Meta-analysis of cognitive behaviour therapy and selective serotonin reuptake inhibitors for the treatment of hypochondriasis: Implications for trial design.", "citation": "Fineberg NA et al. (2022), Compr Psychiatry 118:152334, PMID 36007340", "journal": "Comprehensive psychiatry", "year": 2022, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "36007340", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36007340/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "088f334a3a2d5e79", "topic": "treatment", "quote": "SSRIs vs. Pill Placebo: g = -0.29 [95% CI -0.57 to -0.01], k=3, I²=0%; three included SSRI (N = 193) arms", "quotedFrom": "abstract", "source": { "title": "Meta-analysis of cognitive behaviour therapy and selective serotonin reuptake inhibitors for the treatment of hypochondriasis: Implications for trial design.", "citation": "Fineberg NA et al. (2022), Compr Psychiatry 118:152334, PMID 36007340", "journal": "Comprehensive psychiatry", "year": 2022, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "36007340", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36007340/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "87667b1bc83b2e7a", "topic": "treatment", "quote": "13 randomised controlled trials (RCTs) (N = 1405); 12 included CBT (N = 1212) and three included SSRI (N = 193) arms", "quotedFrom": "abstract", "source": { "title": "Meta-analysis of cognitive behaviour therapy and selective serotonin reuptake inhibitors for the treatment of hypochondriasis: Implications for trial design.", "citation": "Fineberg NA et al. (2022), Compr Psychiatry 118:152334, PMID 36007340", "journal": "Comprehensive psychiatry", "year": 2022, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "36007340", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36007340/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "96f8e12dacfb01ec", "topic": "treatment", "quote": "We found positive effects on depression post-treatment (Hedges' g = 0.12 [95% confidence interval = 0.03-0.2], k = 5) as well as on somatic symptom severity (g = 0.25 [0.096-0.41], k = 17) and health care utilization (g = 0.31 [0.18-0.44], k = 3) at follow-up.", "quotedFrom": "abstract", "source": { "title": "Early Psychological Interventions for Somatic Symptom Disorder and Functional Somatic Syndromes: A Systematic Review and Meta-Analysis.", "citation": "Berezowski L, Ludwig L, Martin A et al.. Early Psychological Interventions for Somatic Symptom Disorder and Functional Somatic Syndromes: A Systematic Review and Meta-Analysis.. Psychosomatic medicine, 2022.", "journal": "Psychosomatic medicine", "year": 2022, "studyDesign": "meta-analysis", "doi": "10.1097/PSY.0000000000001011", "doiUrl": "https://doi.org/10.1097/PSY.0000000000001011", "doiVerifiedAgainstCrossref": true, "pmid": "34524264", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34524264/", "pmcid": "PMC8983947", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8983947/" } }, { "id": "07fc4fc0528d56d2", "topic": "treatment", "quote": "The results proved not to be robust according to publication bias (adjusted OR 1.18, 95%-CI 0.83-1.69) and fail-safe N (2/3 < benchmark N = 75) and are limited due to heterogeneity (I 2 = 57%), small sample sizes and an overall low quality of included studies.", "quotedFrom": "abstract", "source": { "title": "Ethnic and migration-related inequalities in health anxiety: A systematic review and meta-analysis.", "citation": "Barbek R, Henning S, Ludwig J et al.. Ethnic and migration-related inequalities in health anxiety: A systematic review and meta-analysis.. Frontiers in psychology, 2022.", "journal": "Frontiers in psychology", "year": 2022, "studyDesign": "systematic-review", "doi": "10.3389/fpsyg.2022.960256", "doiUrl": "https://doi.org/10.3389/fpsyg.2022.960256", "doiVerifiedAgainstCrossref": true, "pmid": "36092037", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36092037/", "pmcid": "PMC9462455", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462455/" } }, { "id": "c37bbbec2bdfeb4a", "topic": "treatment", "quote": "The pooled effect size indicated a higher risk of health anxiety in migrants and ethnic minorities compared to the majority population (OR 1.39, 95%-CI 1.01-1.92).", "quotedFrom": "abstract", "source": { "title": "Ethnic and migration-related inequalities in health anxiety: A systematic review and meta-analysis.", "citation": "Barbek R, Henning S, Ludwig J et al.. Ethnic and migration-related inequalities in health anxiety: A systematic review and meta-analysis.. Frontiers in psychology, 2022.", "journal": "Frontiers in psychology", "year": 2022, "studyDesign": "systematic-review", "doi": "10.3389/fpsyg.2022.960256", "doiUrl": "https://doi.org/10.3389/fpsyg.2022.960256", "doiVerifiedAgainstCrossref": true, "pmid": "36092037", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36092037/", "pmcid": "PMC9462455", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9462455/" } }, { "id": "103f85fb1d7ea7a0", "topic": "treatment", "quote": "CONCLUSIONS: Although treatment effects were smaller than in the previous uncontrolled trial, I-EAET is a promising treatment for SSD, with a minority of patients (around 20%) experiencing substantial clinical improvement.", "quotedFrom": "abstract", "source": { "title": "Internet-based emotional awareness and expression therapy for somatic symptom disorder: A randomized controlled trial.", "citation": "Maroti D, Lumley MA, Schubiner H et al.. Internet-based emotional awareness and expression therapy for somatic symptom disorder: A randomized controlled trial.. Journal of psychosomatic research, 2022.", "journal": "Journal of psychosomatic research", "year": 2022, "studyDesign": "rct", "doi": "10.1016/j.jpsychores.2022.111068", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2022.111068", "doiVerifiedAgainstCrossref": true, "pmid": "36327532", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36327532/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "475c5c47c36fbd64", "topic": "treatment", "quote": "The number needed to treat was 2.8 (95% CI 1.8-6.1, p < 0.001), and twice as many patients in iACT were no longer clinical cases (35% v. 16%; risk ratio 2.17, 95% CI 1.00-4.70, p = 0.050).", "quotedFrom": "abstract", "source": { "title": "Efficacy of internet-delivered acceptance and commitment therapy for severe health anxiety: results from a randomized, controlled trial.", "citation": "Hoffmann D, et al. Psychol Med 51(15):2685-2695, 2021", "journal": "Psychological medicine", "year": 2021, "studyDesign": "rct", "doi": "10.1017/S0033291720001312", "doiUrl": "https://doi.org/10.1017/S0033291720001312", "doiVerifiedAgainstCrossref": true, "pmid": "32404226", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32404226/", "pmcid": "PMC8579157", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579157/" } }, { "id": "992fa79e67d71b4b", "topic": "treatment", "quote": "Moreover, harm avoidant (d = 0.526 - 0.826) and self-defeating traits (d = 0.892) revealed significant associations with somatization.", "quotedFrom": "abstract", "source": { "title": "Somatization and Somatic Symptom Disorder and its overlap with dimensionally measured personality pathology: A systematic review.", "citation": "Macina C, Bendel R, Walter M et al.. Somatization and Somatic Symptom Disorder and its overlap with dimensionally measured personality pathology: A systematic review.. Journal of psychosomatic research, 2021.", "journal": "Journal of psychosomatic research", "year": 2021, "studyDesign": "systematic-review", "doi": "10.1016/j.jpsychores.2021.110646", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2021.110646", "doiVerifiedAgainstCrossref": true, "pmid": "34715494", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34715494/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "8217c52e7ec39a46", "topic": "treatment", "quote": "It is estimated that individuals with severe health anxiety (HA) utilize 41 %-78 % more healthcare resources than individuals with identified medical diagnoses.", "quotedFrom": "abstract", "source": { "title": "A randomized controlled trial evaluating the efficacy of a brief computerized anxiety sensitivity reduction intervention for health anxiety.", "citation": "O'Bryan EM, McLeish AC, Norr AM et al.. A randomized controlled trial evaluating the efficacy of a brief computerized anxiety sensitivity reduction intervention for health anxiety.. Journal of anxiety disorders, 2021.", "journal": "Journal of anxiety disorders", "year": 2021, "studyDesign": "rct", "doi": "10.1016/j.janxdis.2021.102425", "doiUrl": "https://doi.org/10.1016/j.janxdis.2021.102425", "doiVerifiedAgainstCrossref": true, "pmid": "34082279", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34082279/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "170f637f89c65548", "topic": "treatment", "quote": "Participants were 68 university students (79.4 % female; Mage = 19.68) with elevated levels of AS and HA.", "quotedFrom": "abstract", "source": { "title": "A randomized controlled trial evaluating the efficacy of a brief computerized anxiety sensitivity reduction intervention for health anxiety.", "citation": "O'Bryan EM, McLeish AC, Norr AM et al.. A randomized controlled trial evaluating the efficacy of a brief computerized anxiety sensitivity reduction intervention for health anxiety.. Journal of anxiety disorders, 2021.", "journal": "Journal of anxiety disorders", "year": 2021, "studyDesign": "rct", "doi": "10.1016/j.janxdis.2021.102425", "doiUrl": "https://doi.org/10.1016/j.janxdis.2021.102425", "doiVerifiedAgainstCrossref": true, "pmid": "34082279", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34082279/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "79132bc82637055d", "topic": "treatment", "quote": "A mean difference in change over time of 19.0 points [95% confidence interval (CI) 10.8-27.2, p < 0.001] was shown on the WI-7, and a large standardized effect size of d = 0.80 (95% CI 0.38-1.23) at 6-MFU.", "quotedFrom": "abstract", "source": { "title": "Efficacy of internet-delivered acceptance and commitment therapy for severe health anxiety: results from a randomized, controlled trial.", "citation": "Hoffmann D, Rask CU, Hedman-Lagerlöf E et al.. Efficacy of internet-delivered acceptance and commitment therapy for severe health anxiety: results from a randomized, controlled trial.. Psychological medicine, 2021.", "journal": "Psychological medicine", "year": 2021, "studyDesign": "rct", "doi": "10.1017/S0033291720001312", "doiUrl": "https://doi.org/10.1017/S0033291720001312", "doiVerifiedAgainstCrossref": true, "pmid": "32404226", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32404226/", "pmcid": "PMC8579157", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579157/" } }, { "id": "a465a90ef5c6dfca", "topic": "treatment", "quote": "RESULTS: There was a significant difference in the HAI score in favour of CBT-HA over standard care after 8 years [1.83, 95% confidence interval (CI) 0.25-3.40, p = 0.023], between group differences in generalised anxiety were less (0.54, 95% CI -0.29 to 1.36), p = 0.20, ns), but those for depression were greater at 8 years (1.22, 95% CI 0.42-2.01, p < 0.003) in CBT-HA than in standard care, most in standard care satisfying the criteria for clinical depression.", "quotedFrom": "abstract", "source": { "title": "Sustained benefit of cognitive behaviour therapy for health anxiety in medical patients (CHAMP) over 8 years: a randomised-controlled trial.", "citation": "Tyrer P, Wang D, Crawford M et al.. Sustained benefit of cognitive behaviour therapy for health anxiety in medical patients (CHAMP) over 8 years: a randomised-controlled trial.. Psychological medicine, 2021.", "journal": "Psychological medicine", "year": 2021, "studyDesign": "rct", "doi": "10.1017/S003329172000046X", "doiUrl": "https://doi.org/10.1017/S003329172000046X", "doiVerifiedAgainstCrossref": true, "pmid": "32174296", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32174296/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "d469f134501b7cae", "topic": "treatment", "quote": "Of 444 patients aged 16-75 years seen in cardiology, endocrinology, gastroenterology, neurology and respiratory medicine clinics, 306 (68.9%) were followed-up 8 years after randomisation, including 36 who had died.", "quotedFrom": "abstract", "source": { "title": "Sustained benefit of cognitive behaviour therapy for health anxiety in medical patients (CHAMP) over 8 years: a randomised-controlled trial.", "citation": "Tyrer P, Wang D, Crawford M et al.. Sustained benefit of cognitive behaviour therapy for health anxiety in medical patients (CHAMP) over 8 years: a randomised-controlled trial.. Psychological medicine, 2021.", "journal": "Psychological medicine", "year": 2021, "studyDesign": "rct", "doi": "10.1017/S003329172000046X", "doiUrl": "https://doi.org/10.1017/S003329172000046X", "doiVerifiedAgainstCrossref": true, "pmid": "32174296", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32174296/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "a24bbd5bb8adcefb", "topic": "treatment", "quote": "Response was defined by ≥30% improvement in hypochondriasis.", "quotedFrom": "abstract, Methods", "source": { "title": "Differential Treatment Response Between Hypochondriasis With and Without Prominent Somatic Symptoms.", "citation": "Scarella TM, Boland RJ, Barsky AJ, et al. Front Psychiatry 12:766088, 2021", "journal": "Frontiers in psychiatry", "year": 2021, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "34819881", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34819881/", "pmcid": "PMC8606807", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606807/" } }, { "id": "11a2d9a0505a0da6", "topic": "treatment", "quote": "204 patients total (102 per group); noninferiority margin '2.25 points on the Health Anxiety Inventory'; Between-Group Difference (ITT): B = 0.00; upper limit: 1.98", "quotedFrom": "abstract", "source": { "title": "Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial.", "citation": "Axelsson E et al. (2020), JAMA Psychiatry 77(9):915-924, PMID 32401286", "journal": "JAMA psychiatry", "year": 2020, "studyDesign": "rct", "doi": "10.1001/jamapsychiatry.2020.0940", "doiUrl": "https://doi.org/10.1001/jamapsychiatry.2020.0940", "doiVerifiedAgainstCrossref": true, "pmid": "32401286", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32401286/", "pmcid": "PMC7221860", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221860/" } }, { "id": "54b5722a68292744", "topic": "treatment", "quote": "The primary analysis indicated that the mean score on the Illness Attitudes Scales had increased by 4.61 points (95 % CI: 1.02, 8.20) from 1985 to 2017.", "quotedFrom": "abstract", "source": { "title": "Three decades of increase in health anxiety: Systematic review and meta-analysis of birth cohort changes in university student samples from 1985 to 2017.", "citation": "Kosic A, Lindholm P, Järvholm K et al.. Three decades of increase in health anxiety: Systematic review and meta-analysis of birth cohort changes in university student samples from 1985 to 2017.. Journal of anxiety disorders, 2020.", "journal": "Journal of anxiety disorders", "year": 2020, "studyDesign": "meta-analysis", "doi": "10.1016/j.janxdis.2020.102208", "doiUrl": "https://doi.org/10.1016/j.janxdis.2020.102208", "doiVerifiedAgainstCrossref": true, "pmid": "32172210", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32172210/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "1c1c8832c7456fb1", "topic": "treatment", "quote": "The 1-sided 95% CI upper limits for the internet-delivered CBT vs face-to-face CBT difference in change were within the noninferiority margin in the intention-to-treat analysis (B = 0.00; upper limit: 1.98; Cohen d = 0.00; upper limit: 0.23) and per-protocol analysis (B = 0.01; upper limit: 2.17; Cohen d = 0.00; upper limit: 0.25).", "quotedFrom": "abstract", "source": { "title": "Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial.", "citation": "Axelsson E, Andersson E, Ljótsson B et al.. Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial.. JAMA psychiatry, 2020.", "journal": "JAMA psychiatry", "year": 2020, "studyDesign": "rct", "doi": "10.1001/jamapsychiatry.2020.0940", "doiUrl": "https://doi.org/10.1001/jamapsychiatry.2020.0940", "doiVerifiedAgainstCrossref": true, "pmid": "32401286", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32401286/", "pmcid": "PMC7221860", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221860/" } }, { "id": "096121c3870544ba", "topic": "treatment", "quote": "Of 204 patients, 102 (50%) were randomized to internet-delivered CBT, and 102 (50%) were randomized to face-to-face CBT.", "quotedFrom": "abstract", "source": { "title": "Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial.", "citation": "Axelsson E, Andersson E, Ljótsson B et al.. Effect of Internet vs Face-to-Face Cognitive Behavior Therapy for Health Anxiety: A Randomized Noninferiority Clinical Trial.. JAMA psychiatry, 2020.", "journal": "JAMA psychiatry", "year": 2020, "studyDesign": "rct", "doi": "10.1001/jamapsychiatry.2020.0940", "doiUrl": "https://doi.org/10.1001/jamapsychiatry.2020.0940", "doiVerifiedAgainstCrossref": true, "pmid": "32401286", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32401286/", "pmcid": "PMC7221860", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221860/" } }, { "id": "ea3ddff88dc8e083", "topic": "treatment", "quote": "Intention-to-treat analyses indicated that the iCBT group experienced greater improvements in health anxiety on the Short Health Anxiety Inventory (SHAI) compared to controls (between-groups effect size = 1.39, 95% confidence interval [0.87, 1.93]), and a greater proportion of the iCBT group showed clinically reliable change on the SHAI (84% vs. 34% in the control group).", "quotedFrom": "abstract", "source": { "title": "Internet-based cognitive behavioral therapy versus psychoeducation control for illness anxiety disorder and somatic symptom disorder: A randomized controlled trial.", "citation": "Newby JM, Smith J, Uppal S et al.. Internet-based cognitive behavioral therapy versus psychoeducation control for illness anxiety disorder and somatic symptom disorder: A randomized controlled trial.. Journal of consulting and clinical psychology, 2018.", "journal": "Journal of consulting and clinical psychology", "year": 2018, "studyDesign": "rct", "doi": "10.1037/ccp0000248", "doiUrl": "https://doi.org/10.1037/ccp0000248", "doiVerifiedAgainstCrossref": true, "pmid": "29172593", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/29172593/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "e4359b28538f0b4b", "topic": "treatment", "quote": "RESULTS: Meta-analysis was conducted on 21 comparisons and a large effect size for CBT compared with a control condition was found at post therapy d = 1.01 (95% confidence interval 0.77-1.25), as well as at 6- and 12-month follow-up.", "quotedFrom": "abstract", "source": { "title": "Cognitive Behaviour Therapy for Health Anxiety: A Systematic Review and Meta-Analysis.", "citation": "Cooper K, Gregory JD, Walker I et al.. Cognitive Behaviour Therapy for Health Anxiety: A Systematic Review and Meta-Analysis.. Behavioural and cognitive psychotherapy, 2017.", "journal": "Behavioural and cognitive psychotherapy", "year": 2017, "studyDesign": "meta-analysis", "doi": "10.1017/S1352465816000527", "doiUrl": "https://doi.org/10.1017/S1352465816000527", "doiVerifiedAgainstCrossref": true, "pmid": "28229805", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28229805/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "d04dc530540fca38", "topic": "treatment", "quote": "RESULTS: Linear mixed effects models analysis showed a significant interaction effect of group and time indicating superior improvements in SRH in exposure-based CBT compared to the control condition (Z=2.69, p=0.007).", "quotedFrom": "abstract", "source": { "title": "The impact of exposure-based cognitive behavior therapy for severe health anxiety on self-rated health: Results from a randomized trial.", "citation": "Hedman-Lagerlöf E, Axelsson E, Andersson E et al.. The impact of exposure-based cognitive behavior therapy for severe health anxiety on self-rated health: Results from a randomized trial.. Journal of psychosomatic research, 2017.", "journal": "Journal of psychosomatic research", "year": 2017, "studyDesign": "rct", "doi": "10.1016/j.jpsychores.2017.09.013", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2017.09.013", "doiVerifiedAgainstCrossref": true, "pmid": "29167052", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/29167052/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5305f4bb35667439", "topic": "treatment", "quote": "The controlled effect size was moderately large (d=0.64) and improvements were stable at 1-year follow-up.", "quotedFrom": "abstract", "source": { "title": "The impact of exposure-based cognitive behavior therapy for severe health anxiety on self-rated health: Results from a randomized trial.", "citation": "Hedman-Lagerlöf E, Axelsson E, Andersson E et al.. The impact of exposure-based cognitive behavior therapy for severe health anxiety on self-rated health: Results from a randomized trial.. Journal of psychosomatic research, 2017.", "journal": "Journal of psychosomatic research", "year": 2017, "studyDesign": "rct", "doi": "10.1016/j.jpsychores.2017.09.013", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2017.09.013", "doiVerifiedAgainstCrossref": true, "pmid": "29167052", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/29167052/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "9575ec1e2221bb60", "topic": "treatment", "quote": "Differences in the generalised anxiety (p = 0.0018) and depression scores (p = 0.0065) on the HADS were similar in both groups over the 5-year period.", "quotedFrom": "abstract", "source": { "title": "Cognitive-behaviour therapy for health anxiety in medical patients (CHAMP): a randomised controlled trial with outcomes to 5 years.", "citation": "Tyrer P, Salkovskis P, Tyrer H et al.. Cognitive-behaviour therapy for health anxiety in medical patients (CHAMP): a randomised controlled trial with outcomes to 5 years.. Health technology assessment (Winchester, England), 2017.", "journal": "Health technology assessment (Winchester, England)", "year": 2017, "studyDesign": "rct", "doi": "10.3310/hta21500", "doiUrl": "https://doi.org/10.3310/hta21500", "doiVerifiedAgainstCrossref": true, "pmid": "28877841", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28877841/", "pmcid": "PMC5601246", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601246/" } }, { "id": "8886ac2583b6d927", "topic": "treatment", "quote": "Improvement in HAI scores at 3 months was significantly greater in the CBT-HA group (mean number of sessions = 6) than in the standard care, and this was maintained over the 5-year period (overall p < 0.0001), with no loss of efficacy between 2 and 5 years.", "quotedFrom": "abstract", "source": { "title": "Cognitive-behaviour therapy for health anxiety in medical patients (CHAMP): a randomised controlled trial with outcomes to 5 years.", "citation": "Tyrer P, Salkovskis P, Tyrer H et al.. Cognitive-behaviour therapy for health anxiety in medical patients (CHAMP): a randomised controlled trial with outcomes to 5 years.. Health technology assessment (Winchester, England), 2017.", "journal": "Health technology assessment (Winchester, England)", "year": 2017, "studyDesign": "rct", "doi": "10.3310/hta21500", "doiUrl": "https://doi.org/10.3310/hta21500", "doiVerifiedAgainstCrossref": true, "pmid": "28877841", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28877841/", "pmcid": "PMC5601246", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601246/" } }, { "id": "1d9e53e97e4cd9a9", "topic": "treatment", "quote": "RESULTS: The predicted pattern of response was statistically significant, as shown by the following responder rates: joint treatment group, 47.2%; single active treatment group, 41.8%; and placebo group, 29.6%.", "quotedFrom": "abstract", "source": { "title": "A Randomized Controlled Trial of Medication and Cognitive-Behavioral Therapy for Hypochondriasis.", "citation": "Fallon BA, Ahern DK, Pavlicova M et al.. A Randomized Controlled Trial of Medication and Cognitive-Behavioral Therapy for Hypochondriasis.. The American journal of psychiatry, 2017.", "journal": "The American journal of psychiatry", "year": 2017, "studyDesign": "rct", "doi": "10.1176/appi.ajp.2017.16020189", "doiUrl": "https://doi.org/10.1176/appi.ajp.2017.16020189", "doiVerifiedAgainstCrossref": true, "pmid": "28659038", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28659038/", "pmcid": "PMC5957509", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957509/" } }, { "id": "4db3902e80a2982d", "topic": "treatment", "quote": "Because approximately 50% of patients did not respond to the study treatments, new or more intensive approaches are needed.", "quotedFrom": "abstract", "source": { "title": "A Randomized Controlled Trial of Medication and Cognitive-Behavioral Therapy for Hypochondriasis.", "citation": "Fallon BA, Ahern DK, Pavlicova M et al.. A Randomized Controlled Trial of Medication and Cognitive-Behavioral Therapy for Hypochondriasis.. The American journal of psychiatry, 2017.", "journal": "The American journal of psychiatry", "year": 2017, "studyDesign": "rct", "doi": "10.1176/appi.ajp.2017.16020189", "doiUrl": "https://doi.org/10.1176/appi.ajp.2017.16020189", "doiVerifiedAgainstCrossref": true, "pmid": "28659038", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28659038/", "pmcid": "PMC5957509", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957509/" } }, { "id": "71ee5bacf0949490", "topic": "treatment", "quote": "RESULTS: Statistically significant indirect effects (IE) of ACT-G on the outcome of illness worry 6 months after treatment were found for PF (IE = -5.5, BCa 99% CI -12.3;-1.2) and one mindfulness subscale, namely 'non-react' (IE = -6.5 BCa 99% CI -15.3: 1.0).", "quotedFrom": "abstract", "source": { "title": "Intervening variables in group-based acceptance & commitment therapy for severe health anxiety.", "citation": "Eilenberg T, Hoffmann D, Jensen JS et al.. Intervening variables in group-based acceptance & commitment therapy for severe health anxiety.. Behaviour research and therapy, 2017.", "journal": "Behaviour research and therapy", "year": 2017, "studyDesign": "rct", "doi": "10.1016/j.brat.2017.01.009", "doiUrl": "https://doi.org/10.1016/j.brat.2017.01.009", "doiVerifiedAgainstCrossref": true, "pmid": "28196772", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28196772/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "a45ae8de2203fdfe", "topic": "treatment", "quote": "The primary analysis assessed outcome at week 24 among the intent-to-treat sample, with responders defined as having a 25% or greater improvement over baseline on both the Whiteley Index and a modified version of the Yale-Brown Obsessive Compulsive Scale for hypochondriasis (H-YBOCS-M).", "quotedFrom": "abstract, Methods", "source": { "title": "A Randomized Controlled Trial of Medication and Cognitive-Behavioral Therapy for Hypochondriasis.", "citation": "Fallon BA, Ahern DK, Pavlicova M, et al. Am J Psychiatry 174(8):756-764, 2017", "journal": "The American journal of psychiatry", "year": 2017, "studyDesign": "rct", "doi": "10.1176/appi.ajp.2017.16020189", "doiUrl": "https://doi.org/10.1176/appi.ajp.2017.16020189", "doiVerifiedAgainstCrossref": true, "pmid": "28659038", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28659038/", "pmcid": "PMC5957509", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957509/" } }, { "id": "04dc0c1633be709e", "topic": "treatment", "quote": "RESULTS: Intention-to-treat analysis showed a statistically significant mean difference of 20.5 points [95% confidence interval (CI) 11.7-29.4, p < 0.001] on the WI between the groups at 10 months, and the between-group effect sizes were large (Cohen's d = 0.89, 95% CI 0.50-1.29).", "quotedFrom": "abstract", "source": { "title": "Acceptance and commitment group therapy (ACT-G) for health anxiety: a randomized controlled trial.", "citation": "Eilenberg T, Fink P, Jensen JS, Rief W, Frostholm L. Psychol Med 46(1):103-115, 2016", "journal": "Psychological medicine", "year": 2016, "studyDesign": "rct", "doi": "10.1017/S0033291715001579", "doiUrl": "https://doi.org/10.1017/S0033291715001579", "doiVerifiedAgainstCrossref": true, "pmid": "26281857", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26281857/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "84dd758fb8f33172", "topic": "treatment", "quote": "RESULTS: Compared with the WL, both CT and ET reduced the frequency of somatic attributions regarding severe diseases (CT: Hedges's g = 1.12; ET: Hedges's g = 1.03) and increased the frequency of normalizing attributions (CT: Hedges's g = 1.17; ET: Hedges's g = 1.24).", "quotedFrom": "abstract", "source": { "title": "Changes in Free Symptom Attributions in Hypochondriasis after Cognitive Therapy and Exposure Therapy.", "citation": "Schwind J, Neng JM, Weck F. Changes in Free Symptom Attributions in Hypochondriasis after Cognitive Therapy and Exposure Therapy.. Behavioural and cognitive psychotherapy, 2016.", "journal": "Behavioural and cognitive psychotherapy", "year": 2016, "studyDesign": "rct", "doi": "10.1017/S1352465816000163", "doiUrl": "https://doi.org/10.1017/S1352465816000163", "doiVerifiedAgainstCrossref": true, "pmid": "27126076", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/27126076/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "d5b6d4ba856bbb97", "topic": "treatment", "quote": "Only CT changed the attributions regarding moderate diseases (Hedges's g = 0.69).", "quotedFrom": "abstract", "source": { "title": "Changes in Free Symptom Attributions in Hypochondriasis after Cognitive Therapy and Exposure Therapy.", "citation": "Schwind J, Neng JM, Weck F. Changes in Free Symptom Attributions in Hypochondriasis after Cognitive Therapy and Exposure Therapy.. Behavioural and cognitive psychotherapy, 2016.", "journal": "Behavioural and cognitive psychotherapy", "year": 2016, "studyDesign": "rct", "doi": "10.1017/S1352465816000163", "doiUrl": "https://doi.org/10.1017/S1352465816000163", "doiVerifiedAgainstCrossref": true, "pmid": "27126076", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/27126076/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "388abaadd29c08c4", "topic": "treatment", "quote": "Patients with higher dependent traits received significantly more treatment sessions (8.6) than those with low trait levels (5.4) (p < 0.01).", "quotedFrom": "abstract", "source": { "title": "Dimensions of dependence and their influence on the outcome of cognitive behaviour therapy for health anxiety: randomized controlled trial.", "citation": "Tyrer P, Wang D, Tyrer H et al.. Dimensions of dependence and their influence on the outcome of cognitive behaviour therapy for health anxiety: randomized controlled trial.. Personality and mental health, 2016.", "journal": "Personality and mental health", "year": 2016, "studyDesign": "rct", "doi": "10.1002/pmh.1339", "doiUrl": "https://doi.org/10.1002/pmh.1339", "doiVerifiedAgainstCrossref": true, "pmid": "27120420", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/27120420/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "1ba9c33bda341a5d", "topic": "treatment", "quote": "The number needed to treat was 2.4 (95% CI 1.4-3.4, p < 0.001).", "quotedFrom": "abstract", "source": { "title": "Acceptance and commitment group therapy (ACT-G) for health anxiety: a randomized controlled trial.", "citation": "Eilenberg T, Fink P, Jensen JS et al.. Acceptance and commitment group therapy (ACT-G) for health anxiety: a randomized controlled trial.. Psychological medicine, 2016.", "journal": "Psychological medicine", "year": 2016, "studyDesign": "rct", "doi": "10.1017/S0033291715001579", "doiUrl": "https://doi.org/10.1017/S0033291715001579", "doiVerifiedAgainstCrossref": true, "pmid": "26281857", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26281857/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "b9bc7aef8a9e6f55", "topic": "treatment", "quote": "RESULTS: Both CT (Hedges's g = 1.01-1.11) and ET (Hedges's g = 1.21-1.24) demonstrated their efficacy in comparison with the WL in the primary outcome measure.", "quotedFrom": "abstract (auto-extracted verbatim)", "source": { "title": "Cognitive therapy versus exposure therapy for hypochondriasis (health anxiety): A randomized controlled trial.", "citation": "Weck F, Neng JMB, Richtberg S, Jakob M, Stangier U. J Consult Clin Psychol 83(4):665-676, 2015", "journal": "Journal of consulting and clinical psychology", "year": 2015, "studyDesign": "rct", "doi": "10.1037/ccp0000013", "doiUrl": "https://doi.org/10.1037/ccp0000013", "doiVerifiedAgainstCrossref": true, "pmid": "25495359", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25495359/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "54392a7cbc3d2cfb", "topic": "treatment", "quote": "At posttreatment, response was found for 72.0% and remission for 45.3% of the patients.", "quotedFrom": "abstract", "source": { "title": "Response and Remission After Cognitive and Exposure Therapy for Hypochondriasis.", "citation": "Weck F, Neng JM. Response and Remission After Cognitive and Exposure Therapy for Hypochondriasis.. The Journal of nervous and mental disease, 2015.", "journal": "The Journal of nervous and mental disease", "year": 2015, "studyDesign": "rct", "doi": "10.1097/NMD.0000000000000385", "doiUrl": "https://doi.org/10.1097/NMD.0000000000000385", "doiVerifiedAgainstCrossref": true, "pmid": "26513512", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26513512/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "073aecd935744579", "topic": "treatment", "quote": "At 12-month follow-up, the response rate was 68.0%, and the remission rate was 54.7%.", "quotedFrom": "abstract", "source": { "title": "Response and Remission After Cognitive and Exposure Therapy for Hypochondriasis.", "citation": "Weck F, Neng JM. Response and Remission After Cognitive and Exposure Therapy for Hypochondriasis.. The Journal of nervous and mental disease, 2015.", "journal": "The Journal of nervous and mental disease", "year": 2015, "studyDesign": "rct", "doi": "10.1097/NMD.0000000000000385", "doiUrl": "https://doi.org/10.1097/NMD.0000000000000385", "doiVerifiedAgainstCrossref": true, "pmid": "26513512", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26513512/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "7440caa2e477f46f", "topic": "treatment", "quote": "The current study was based on a randomized controlled trial and compared patients with hypochondriasis (N=73) receiving ET or cognitive therapy (CT) to a wait list (WL) control group.", "quotedFrom": "abstract", "source": { "title": "Exposure therapy changes dysfunctional evaluations of somatic symptoms in patients with hypochondriasis (health anxiety). A randomized controlled trial.", "citation": "Weck F, Neng JM, Schwind J et al.. Exposure therapy changes dysfunctional evaluations of somatic symptoms in patients with hypochondriasis (health anxiety). A randomized controlled trial.. Journal of anxiety disorders, 2015.", "journal": "Journal of anxiety disorders", "year": 2015, "studyDesign": "rct", "doi": "10.1016/j.janxdis.2015.05.008", "doiUrl": "https://doi.org/10.1016/j.janxdis.2015.05.008", "doiVerifiedAgainstCrossref": true, "pmid": "26093823", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26093823/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "1bd7b4ce7971da6d", "topic": "treatment", "quote": "Based on complete register data, we (1) compared weeks on sickness-related benefits (SB) in untreated patients with severe HA (n=126) with a matched population sample (n=12,600); and (2) tested whether Acceptance & Commitment group Therapy (ACT-G) (n=63) reduced weeks on SB during the first year after randomisation compared to a waitlist (n=63).", "quotedFrom": "abstract", "source": { "title": "Long-term consequences of severe health anxiety on sick leave in treated and untreated patients: Analysis alongside a randomised controlled trial.", "citation": "Eilenberg T, Frostholm L, Schröder A et al.. Long-term consequences of severe health anxiety on sick leave in treated and untreated patients: Analysis alongside a randomised controlled trial.. Journal of anxiety disorders, 2015.", "journal": "Journal of anxiety disorders", "year": 2015, "studyDesign": "rct", "doi": "10.1016/j.janxdis.2015.04.001", "doiUrl": "https://doi.org/10.1016/j.janxdis.2015.04.001", "doiVerifiedAgainstCrossref": true, "pmid": "25935314", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25935314/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "2b179ae7be2a3bed", "topic": "treatment", "quote": "We found that (1) HA patients showed a six-monthly increment of 2 weeks on SB compared with the general population (p<0.0001), and (2) that ACT-G and the waitlist showed no difference in their ability to reduce SB during the first year (p=0.246).", "quotedFrom": "abstract", "source": { "title": "Long-term consequences of severe health anxiety on sick leave in treated and untreated patients: Analysis alongside a randomised controlled trial.", "citation": "Eilenberg T, Frostholm L, Schröder A et al.. Long-term consequences of severe health anxiety on sick leave in treated and untreated patients: Analysis alongside a randomised controlled trial.. Journal of anxiety disorders, 2015.", "journal": "Journal of anxiety disorders", "year": 2015, "studyDesign": "rct", "doi": "10.1016/j.janxdis.2015.04.001", "doiUrl": "https://doi.org/10.1016/j.janxdis.2015.04.001", "doiVerifiedAgainstCrossref": true, "pmid": "25935314", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25935314/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "ad299a8e2f9bfd6c", "topic": "treatment", "quote": "RESULTS: After the 2-week period, the AMTG compared with the CG reported lower symptoms of pathological health anxiety, F(1, 82) = 10.94, p < .01, η2p = .12, rated symptom, F(1, 82) = 5.56, p = .02, η2p = .06, and illness words, F(1, 82) = 4.13, p = .045, η2p = .05, as less arousing, and revealed a smaller memory response bias toward symptom words in the recognition task F(1, 82) = 12.32, p < .01, η2p = .13.", "quotedFrom": "abstract", "source": { "title": "A diary-based modification of symptom attributions in pathological health anxiety: effects on symptom report and cognitive biases.", "citation": "Kerstner T, Witthöft M, Mier D et al.. A diary-based modification of symptom attributions in pathological health anxiety: effects on symptom report and cognitive biases.. Journal of consulting and clinical psychology, 2015.", "journal": "Journal of consulting and clinical psychology", "year": 2015, "studyDesign": "rct", "doi": "10.1037/a0039056", "doiUrl": "https://doi.org/10.1037/a0039056", "doiVerifiedAgainstCrossref": true, "pmid": "25822241", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25822241/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "460bb4127ec4ecee", "topic": "treatment", "quote": "Those treated by nurses (n=66) had improvement in health anxiety, generalised anxiety and depression outcomes that were significantly better and twice as great as those of the professional groups of assistant psychologists (n=87) and graduate workers (n=66) (P<0.01 over all time points).", "quotedFrom": "abstract", "source": { "title": "Therapist differences in a randomised trial of the outcome of cognitive behaviour therapy for health anxiety in medical patients.", "citation": "Tyrer H, Tyrer P, Lisseman-Stones Y et al.. Therapist differences in a randomised trial of the outcome of cognitive behaviour therapy for health anxiety in medical patients.. International journal of nursing studies, 2015.", "journal": "International journal of nursing studies", "year": 2015, "studyDesign": "rct", "doi": "10.1016/j.ijnurstu.2014.11.013", "doiUrl": "https://doi.org/10.1016/j.ijnurstu.2014.11.013", "doiVerifiedAgainstCrossref": true, "pmid": "25542343", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25542343/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5b0817be779cba1e", "topic": "treatment", "quote": "RESULTS: 444 patients were randomised in the trial, 219 to cognitive behaviour therapy adapted health anxiety and 225 to standard care. 373 (84%) completed assessments after two years.", "quotedFrom": "abstract", "source": { "title": "Therapist differences in a randomised trial of the outcome of cognitive behaviour therapy for health anxiety in medical patients.", "citation": "Tyrer H, Tyrer P, Lisseman-Stones Y et al.. Therapist differences in a randomised trial of the outcome of cognitive behaviour therapy for health anxiety in medical patients.. International journal of nursing studies, 2015.", "journal": "International journal of nursing studies", "year": 2015, "studyDesign": "rct", "doi": "10.1016/j.ijnurstu.2014.11.013", "doiUrl": "https://doi.org/10.1016/j.ijnurstu.2014.11.013", "doiVerifiedAgainstCrossref": true, "pmid": "25542343", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25542343/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "65726ee077edac15", "topic": "treatment", "quote": "Using data from a recently conducted RCT comparing ICBT (n = 79) with Internet-delivered behavioral stress management (IBSM) (n = 79) the presented study investigated predictors of treatment outcome.", "quotedFrom": "abstract", "source": { "title": "Predictors in Internet-delivered cognitive behavior therapy and behavioral stress management for severe health anxiety.", "citation": "Hedman E, Andersson E, Lekander M et al.. Predictors in Internet-delivered cognitive behavior therapy and behavioral stress management for severe health anxiety.. Behaviour research and therapy, 2015.", "journal": "Behaviour research and therapy", "year": 2015, "studyDesign": "rct", "doi": "10.1016/j.brat.2014.11.009", "doiUrl": "https://doi.org/10.1016/j.brat.2014.11.009", "doiVerifiedAgainstCrossref": true, "pmid": "25540862", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25540862/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "20bd540b3aeb971f", "topic": "treatment", "quote": "Data from a randomized controlled trial were used in which participants were allocated to 12 weeks of ICBT (n = 40) or to a basic attention control condition (n = 41).", "quotedFrom": "abstract", "source": { "title": "Personality change following internet-based cognitive behavior therapy for severe health anxiety.", "citation": "Hedman E, Andersson G, Lindefors N et al.. Personality change following internet-based cognitive behavior therapy for severe health anxiety.. PloS one, 2014.", "journal": "PloS one", "year": 2014, "studyDesign": "rct", "doi": "10.1371/journal.pone.0113871", "doiUrl": "https://doi.org/10.1371/journal.pone.0113871", "doiVerifiedAgainstCrossref": true, "pmid": "25437150", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25437150/", "pmcid": "PMC4250052", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250052/" } }, { "id": "7eb1fdf4704919ee", "topic": "treatment", "quote": "RESULTS: The patient group had significantly higher scores on the SAS, HAI-1, and HAI-T scales compared to controls (P < 0.001, P = 0.006, and P = 0.038, resp.).", "quotedFrom": "abstract", "source": { "title": "Evaluation of alexithymia, somatosensory sensitivity, and health anxiety levels in patients with noncardiac chest pain.", "citation": "Zincir SB, Sunbul M, Sunbul EA et al.. Evaluation of alexithymia, somatosensory sensitivity, and health anxiety levels in patients with noncardiac chest pain.. BioMed research international, 2014.", "journal": "BioMed research international", "year": 2014, "studyDesign": "rct", "doi": "10.1155/2014/896183", "doiUrl": "https://doi.org/10.1155/2014/896183", "doiVerifiedAgainstCrossref": true, "pmid": "24967410", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24967410/", "pmcid": "PMC4055647", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055647/" } }, { "id": "53ee0d71c83ce1d6", "topic": "treatment", "quote": "SAS, HAI-1, and HAI-T scores were significantly higher in female patients than male (P = 0.002, 0.036, and 0.039, resp.).", "quotedFrom": "abstract", "source": { "title": "Evaluation of alexithymia, somatosensory sensitivity, and health anxiety levels in patients with noncardiac chest pain.", "citation": "Zincir SB, Sunbul M, Sunbul EA et al.. Evaluation of alexithymia, somatosensory sensitivity, and health anxiety levels in patients with noncardiac chest pain.. BioMed research international, 2014.", "journal": "BioMed research international", "year": 2014, "studyDesign": "rct", "doi": "10.1155/2014/896183", "doiUrl": "https://doi.org/10.1155/2014/896183", "doiVerifiedAgainstCrossref": true, "pmid": "24967410", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24967410/", "pmcid": "PMC4055647", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055647/" } }, { "id": "8883d7b3efb3f725", "topic": "treatment", "quote": "As expected, patients with a sudden gain showed larger improvements than patients without a sudden gain at post-treatment (d = 1.04) and at one-year follow-up (d = 0.91) on measures of health anxiety.", "quotedFrom": "abstract", "source": { "title": "Sudden gains in internet-based cognitive behaviour therapy for severe health anxiety.", "citation": "Hedman E, Lekander M, Ljótsson B et al.. Sudden gains in internet-based cognitive behaviour therapy for severe health anxiety.. Behaviour research and therapy, 2014.", "journal": "Behaviour research and therapy", "year": 2014, "studyDesign": "rct", "doi": "10.1016/j.brat.2013.12.007", "doiUrl": "https://doi.org/10.1016/j.brat.2013.12.007", "doiVerifiedAgainstCrossref": true, "pmid": "24468920", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24468920/", "pmcid": "PMC3943582", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943582/" } }, { "id": "55b11721fca76c5c", "topic": "treatment", "quote": "RESULTS: Thirteen participants (16%) experienced one sudden gain in health anxiety with individual sudden gains distributed across the treatment.", "quotedFrom": "abstract", "source": { "title": "Sudden gains in internet-based cognitive behaviour therapy for severe health anxiety.", "citation": "Hedman E, Lekander M, Ljótsson B et al.. Sudden gains in internet-based cognitive behaviour therapy for severe health anxiety.. Behaviour research and therapy, 2014.", "journal": "Behaviour research and therapy", "year": 2014, "studyDesign": "rct", "doi": "10.1016/j.brat.2013.12.007", "doiUrl": "https://doi.org/10.1016/j.brat.2013.12.007", "doiVerifiedAgainstCrossref": true, "pmid": "24468920", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24468920/", "pmcid": "PMC3943582", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943582/" } }, { "id": "c0b74fef6899328e", "topic": "treatment", "quote": "This study examined the impact of rumination on memory and future thinking among 60 undergraduate participants with varying health anxiety (35% clinical-level health anxiety).", "quotedFrom": "abstract", "source": { "title": "Imagining the future in health anxiety: the impact of rumination on the specificity of illness-related memory and future thinking.", "citation": "Sansom-Daly UM, Bryant RA, Cohn RJ et al.. Imagining the future in health anxiety: the impact of rumination on the specificity of illness-related memory and future thinking.. Anxiety, stress, and coping, 2014.", "journal": "Anxiety, stress, and coping", "year": 2014, "studyDesign": "rct", "doi": "10.1080/10615806.2014.880111", "doiUrl": "https://doi.org/10.1080/10615806.2014.880111", "doiVerifiedAgainstCrossref": true, "pmid": "24392700", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24392700/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "8ec23aee3d91dc4a", "topic": "treatment", "quote": "We performed three types of analyses on data from a sample comprising participants (N = 81) who had received Internet-based CBT in a randomized controlled trial.", "quotedFrom": "abstract", "source": { "title": "Predictors of outcome in Internet-based cognitive behavior therapy for severe health anxiety.", "citation": "Hedman E, Lindefors N, Andersson G et al.. Predictors of outcome in Internet-based cognitive behavior therapy for severe health anxiety.. Behaviour research and therapy, 2013.", "journal": "Behaviour research and therapy", "year": 2013, "studyDesign": "rct", "doi": "10.1016/j.brat.2013.07.009", "doiUrl": "https://doi.org/10.1016/j.brat.2013.07.009", "doiVerifiedAgainstCrossref": true, "pmid": "23994252", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/23994252/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "f2e2470df8569528", "topic": "treatment", "quote": "Significantly, more participants in the SCBT (66.7%) and ECBT (55.6%) conditions demonstrated clinically significant change on health anxiety compared to the WLC condition (11%).", "quotedFrom": "abstract", "source": { "title": "A randomized trial of two forms of cognitive behaviour therapy for an older adult population with subclinical health anxiety.", "citation": "Bourgault-Fagnou MD, Hadjistavropoulos HD. A randomized trial of two forms of cognitive behaviour therapy for an older adult population with subclinical health anxiety.. Cognitive behaviour therapy, 2013.", "journal": "Cognitive behaviour therapy", "year": 2013, "studyDesign": "rct", "doi": "10.1080/16506073.2012.717302", "doiUrl": "https://doi.org/10.1080/16506073.2012.717302", "doiVerifiedAgainstCrossref": true, "pmid": "23205593", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/23205593/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "c39e53fad9022025", "topic": "treatment", "quote": "RESULTS: The BP scale and the WI-7 discriminated significantly between patients with hypochondriasis and those with an anxiety disorder (d=2.42 and d=2.34).", "quotedFrom": "abstract", "source": { "title": "Assessing Bodily Preoccupations is sufficient: clinically effective screening for hypochondriasis.", "citation": "Höfling V, Weck F. Assessing Bodily Preoccupations is sufficient: clinically effective screening for hypochondriasis.. Journal of psychosomatic research, 2013.", "journal": "Journal of psychosomatic research", "year": 2013, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "24290041", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24290041/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "9e973b5aa4d990dd", "topic": "treatment", "quote": "MBCT + Usual Services: n=36; Usual Services alone: n=38; Post-Treatment ITT d=0.48; 1-Year Follow-Up ITT d=0.48; Post-Treatment: MBCT 50.0% vs Usual Services 78.9%; 1-Year Follow-Up: MBCT 36.1% vs Usual Services 76.3%", "quotedFrom": "abstract", "source": { "title": "A randomized clinical trial of mindfulness-based cognitive therapy versus unrestricted services for health anxiety (hypochondriasis).", "citation": "McManus F et al. (2012), J Consult Clin Psychol, PMID 22708977", "journal": "Journal of consulting and clinical psychology", "year": 2012, "studyDesign": "rct", "doi": "10.1037/a0028782", "doiUrl": "https://doi.org/10.1037/a0028782", "doiVerifiedAgainstCrossref": true, "pmid": "22708977", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/22708977/", "pmcid": "PMC3450431", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3450431/" } }, { "id": "c51c1dbc4e239f48", "topic": "treatment", "quote": "Significantly fewer participants allocated to MBCT than to US met criteria for the diagnosis of hypochondriasis, both immediately following the intervention period (ITT 50.0% vs. 78.9%; PP 47.1% vs. 78.4%) and at 1-year follow-up (ITT 36.1% vs. 76.3%; PP 28.1% vs. 75.0%).", "quotedFrom": "abstract", "source": { "title": "A randomized clinical trial of mindfulness-based cognitive therapy versus unrestricted services for health anxiety (hypochondriasis).", "citation": "McManus F, Surawy C, Muse K et al.. A randomized clinical trial of mindfulness-based cognitive therapy versus unrestricted services for health anxiety (hypochondriasis).. Journal of consulting and clinical psychology, 2012.", "journal": "Journal of consulting and clinical psychology", "year": 2012, "studyDesign": "rct", "doi": "10.1037/a0028782", "doiUrl": "https://doi.org/10.1037/a0028782", "doiVerifiedAgainstCrossref": true, "pmid": "22708977", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/22708977/", "pmcid": "PMC3450431", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3450431/" } }, { "id": "380b2990e4b1f418", "topic": "treatment", "quote": "RESULTS: In the intention-to-treat (ITT) analysis (N = 74), MBCT participants had significantly lower health anxiety than US participants, both immediately following the intervention (Cohen's d = 0.48) and at 1-year follow-up (d = 0.48).", "quotedFrom": "abstract", "source": { "title": "A randomized clinical trial of mindfulness-based cognitive therapy versus unrestricted services for health anxiety (hypochondriasis).", "citation": "McManus F, Surawy C, Muse K et al.. A randomized clinical trial of mindfulness-based cognitive therapy versus unrestricted services for health anxiety (hypochondriasis).. Journal of consulting and clinical psychology, 2012.", "journal": "Journal of consulting and clinical psychology", "year": 2012, "studyDesign": "rct", "doi": "10.1037/a0028782", "doiUrl": "https://doi.org/10.1037/a0028782", "doiVerifiedAgainstCrossref": true, "pmid": "22708977", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/22708977/", "pmcid": "PMC3450431", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3450431/" } }, { "id": "d57690d09a184f1b", "topic": "treatment", "quote": "Ninety-three (51%) patients had CLBP; the SCL90R scores for somatization, depression, phobic anxiety, paranoid ideation, and general severity were significantly higher in CLBP(+) group than in the CLBP(-) group at baseline.", "quotedFrom": "abstract", "source": { "title": "Responsiveness of hypochondriacal patients with chronic low-back pain to cognitive-behavioral therapy.", "citation": "Nakao M, Shinozaki Y, Nolido N et al.. Responsiveness of hypochondriacal patients with chronic low-back pain to cognitive-behavioral therapy.. Psychosomatics, 2012.", "journal": "Psychosomatics", "year": 2012, "studyDesign": "rct", "doi": "10.1016/j.psym.2011.09.006", "doiUrl": "https://doi.org/10.1016/j.psym.2011.09.006", "doiVerifiedAgainstCrossref": true, "pmid": "22424162", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/22424162/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "397c6f930a4f6989", "topic": "treatment", "quote": "METHOD/DESIGN: The study is a randomized controlled trial with two parallel arms and equal randomization of 466 eligible patients (assuming a 20% drop-out) to an active treatment group of 5-10 sessions of cognitive behaviour therapy and to a control group.", "quotedFrom": "abstract", "source": { "title": "CHAMP: Cognitive behaviour therapy for health anxiety in medical patients, a randomised controlled trial.", "citation": "Tyrer P, Cooper S, Tyrer H et al.. CHAMP: Cognitive behaviour therapy for health anxiety in medical patients, a randomised controlled trial.. BMC psychiatry, 2011.", "journal": "BMC psychiatry", "year": 2011, "studyDesign": "rct", "doi": "10.1186/1471-244X-11-99", "doiUrl": "https://doi.org/10.1186/1471-244X-11-99", "doiVerifiedAgainstCrossref": true, "pmid": "21672205", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/21672205/", "pmcid": "PMC3141642", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141642/" } }, { "id": "d2779a4e3768e09b", "topic": "treatment", "quote": "We investigated participants of a German population (n = 1,575) and 61 patients with the Diagnostic and Statistical Manual of Mental Disorders (4th ed. [DSM-IV]; American Psychiatric Association, 1994) diagnosis of hypochondriasis.", "quotedFrom": "abstract", "source": { "title": "Screening for hypochondriasis with the Illness Attitude Scales.", "citation": "Weck F, Bleichhardt G, Hiller W. Screening for hypochondriasis with the Illness Attitude Scales.. Journal of personality assessment, 2010.", "journal": "Journal of personality assessment", "year": 2010, "studyDesign": "other", "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": "20408026", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/20408026/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "34e95b97857ee84c", "topic": "treatment", "quote": "Approximately 50% to 75% of the patients with MUS improve, whereas 10% to 30% of patients with MUS deteriorate.", "quotedFrom": "abstract", "source": { "title": "Medically unexplained symptoms, somatisation disorder and hypochondriasis: course and prognosis. A systematic review.", "citation": "olde Hartman TC, Borghuis MS, Lucassen PL et al.. Medically unexplained symptoms, somatisation disorder and hypochondriasis: course and prognosis. A systematic review.. Journal of psychosomatic research, 2009.", "journal": "Journal of psychosomatic research", "year": 2009, "studyDesign": "systematic-review", "doi": "10.1016/j.jpsychores.2008.09.018", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2008.09.018", "doiVerifiedAgainstCrossref": true, "pmid": "19379952", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/19379952/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "6e4669e816683e24", "topic": "treatment", "quote": "In patients with hypochondriasis, recovery rates vary between 30% and 50%.", "quotedFrom": "abstract", "source": { "title": "Medically unexplained symptoms, somatisation disorder and hypochondriasis: course and prognosis. A systematic review.", "citation": "olde Hartman TC, Borghuis MS, Lucassen PL et al.. Medically unexplained symptoms, somatisation disorder and hypochondriasis: course and prognosis. A systematic review.. Journal of psychosomatic research, 2009.", "journal": "Journal of psychosomatic research", "year": 2009, "studyDesign": "systematic-review", "doi": "10.1016/j.jpsychores.2008.09.018", "doiUrl": "https://doi.org/10.1016/j.jpsychores.2008.09.018", "doiVerifiedAgainstCrossref": true, "pmid": "19379952", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/19379952/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "6cdcd287b316cd1c", "topic": "treatment", "quote": "More patients responded with improvement in hypochondriasis when given fluoxetine compared with placebo, starting at week 8 (50.0% vs 19.0%, P = 0.03) and continuing to week 12 (62.5% vs 33.3%, P = 0.05).", "quotedFrom": "abstract", "source": { "title": "A double-masked, placebo-controlled study of fluoxetine for hypochondriasis.", "citation": "Fallon BA, Petkova E, Skritskaya N et al.. A double-masked, placebo-controlled study of fluoxetine for hypochondriasis.. Journal of clinical psychopharmacology, 2008.", "journal": "Journal of clinical psychopharmacology", "year": 2008, "studyDesign": "rct", "doi": "10.1097/JCP.0b013e31818d21cf", "doiUrl": "https://doi.org/10.1097/JCP.0b013e31818d21cf", "doiVerifiedAgainstCrossref": true, "pmid": "19011432", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/19011432/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "51a1ac010f8df96f", "topic": "treatment", "quote": "The acute treatment response was maintained to week 24 with more responders in the fluoxetine compared with the placebo group (54.2% vs 23.8%, P = 0.04).", "quotedFrom": "abstract", "source": { "title": "A double-masked, placebo-controlled study of fluoxetine for hypochondriasis.", "citation": "Fallon BA, Petkova E, Skritskaya N et al.. A double-masked, placebo-controlled study of fluoxetine for hypochondriasis.. Journal of clinical psychopharmacology, 2008.", "journal": "Journal of clinical psychopharmacology", "year": 2008, "studyDesign": "rct", "doi": "10.1097/JCP.0b013e31818d21cf", "doiUrl": "https://doi.org/10.1097/JCP.0b013e31818d21cf", "doiVerifiedAgainstCrossref": true, "pmid": "19011432", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/19011432/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "277136145e9a8318", "topic": "treatment", "quote": "RESULTS: Greater improvement was seen in Health Anxiety Inventory (HAI) scores (primary outcome) in patients treated with CBT (n=23) than in the control group (n=26) (P=0.001).", "quotedFrom": "abstract", "source": { "title": "Cognitive-behavioural therapy for health anxiety in a genitourinary medicine clinic: randomised controlled trial.", "citation": "Seivewright H, Green J, Salkovskis P et al.. Cognitive-behavioural therapy for health anxiety in a genitourinary medicine clinic: randomised controlled trial.. The British journal of psychiatry : the journal of mental science, 2008.", "journal": "The British journal of psychiatry : the journal of mental science", "year": 2008, "studyDesign": "rct", "doi": "10.1192/bjp.bp.108.052936", "doiUrl": "https://doi.org/10.1192/bjp.bp.108.052936", "doiVerifiedAgainstCrossref": true, "pmid": "18827299", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/18827299/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "b604535118bf44a5", "topic": "treatment", "quote": "Standardised or weighted mean differences were used to pool data for continuous outcomes and odds ratios were used to pool data for dichotomous outcomes, together with 95% confidence intervals.", "quotedFrom": "abstract", "source": { "title": "Psychotherapies for hypochondriasis.", "citation": "Thomson AB, Page LA. Psychotherapies for hypochondriasis.. The Cochrane database of systematic reviews, 2007.", "journal": "The Cochrane database of systematic reviews", "year": 2007, "studyDesign": "meta-analysis", "doi": "10.1002/14651858.CD006520.pub2", "doiUrl": "https://doi.org/10.1002/14651858.CD006520.pub2", "doiVerifiedAgainstCrossref": true, "pmid": "17943915", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/17943915/", "pmcid": "PMC6956615", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956615/" } }, { "id": "7c7675562df037ca", "topic": "treatment", "quote": "All forms of psychotherapy except psychoeducation showed a significant improvement in hypochondriacal symptoms compared to waiting list control (SMD (random) [95% CI] = -0.86 [-1.25 to -0.46]).", "quotedFrom": "abstract", "source": { "title": "Psychotherapies for hypochondriasis.", "citation": "Thomson AB, Page LA. Psychotherapies for hypochondriasis.. The Cochrane database of systematic reviews, 2007.", "journal": "The Cochrane database of systematic reviews", "year": 2007, "studyDesign": "meta-analysis", "doi": "10.1002/14651858.CD006520.pub2", "doiUrl": "https://doi.org/10.1002/14651858.CD006520.pub2", "doiVerifiedAgainstCrossref": true, "pmid": "17943915", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/17943915/", "pmcid": "PMC6956615", "freeFullTextUrl": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956615/" } }, { "id": "feec167bb25142d2", "topic": "treatment", "quote": "The responder analysis on the intent-to-treat cohort and completer cohort, respectively, revealed the following percentages of responders per group: CBT group, 45% and 54%; paroxetine group, 30% and 38%; and placebo group, 14% and 12%.", "quotedFrom": "abstract", "source": { "title": "Cognitive behavior therapy and paroxetine in the treatment of hypochondriasis: a randomized controlled trial.", "citation": "Greeven A, van Balkom AJ, Visser S et al.. Cognitive behavior therapy and paroxetine in the treatment of hypochondriasis: a randomized controlled trial.. The American journal of psychiatry, 2007.", "journal": "The American journal of psychiatry", "year": 2007, "studyDesign": "rct", "doi": "10.1176/ajp.2007.164.1.91", "doiUrl": "https://doi.org/10.1176/ajp.2007.164.1.91", "doiVerifiedAgainstCrossref": true, "pmid": "17202549", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/17202549/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "6cb36739de1fb6bf", "topic": "treatment", "quote": "Participants (N=48, of whom 4 dropped out), suffering from DSM-IV hypochondriasis, were randomized into one of the two course conditions.", "quotedFrom": "abstract", "source": { "title": "Psychoeducation for hypochondriasis: a comparison of a cognitive-behavioural approach and a problem-solving approach.", "citation": "Buwalda FM, Bouman TK, van Duijn MA. Psychoeducation for hypochondriasis: a comparison of a cognitive-behavioural approach and a problem-solving approach.. Behaviour research and therapy, 2007.", "journal": "Behaviour research and therapy", "year": 2007, "studyDesign": "rct", "doi": "10.1016/j.brat.2006.08.004", "doiUrl": "https://doi.org/10.1016/j.brat.2006.08.004", "doiVerifiedAgainstCrossref": true, "pmid": "17055449", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/17055449/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "5557d4e9158a77f1", "topic": "treatment", "quote": "Few differential treatment effects were found: in both conditions all effect measures decreased significantly over time (p<0.01).", "quotedFrom": "abstract", "source": { "title": "Psychoeducation for hypochondriasis: a comparison of a cognitive-behavioural approach and a problem-solving approach.", "citation": "Buwalda FM, Bouman TK, van Duijn MA. Psychoeducation for hypochondriasis: a comparison of a cognitive-behavioural approach and a problem-solving approach.. Behaviour research and therapy, 2007.", "journal": "Behaviour research and therapy", "year": 2007, "studyDesign": "rct", "doi": "10.1016/j.brat.2006.08.004", "doiUrl": "https://doi.org/10.1016/j.brat.2006.08.004", "doiVerifiedAgainstCrossref": true, "pmid": "17055449", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/17055449/", "pmcid": null, "freeFullTextUrl": null } }, { "id": "f1ccdb30f3aba1b7", "topic": "treatment", "quote": "Initial sample: 444 patients; 8-year follow-up: 306 patients (68.9%), including 36 who had died; 'a significant difference in the HAI score in favour of CBT-HA over standard care after 8 years [1.83, 95% CI 0.25–3.40, p = 0.023]'; Generalized Anxiety: 0.54, 95% CI −0.29 to 1.36, p=0.20 (not significant); Depression: 1.22, 95% CI 0.42–2.01, p<0.003, greater improvement with CBT-HA", "quotedFrom": "full text (via Cambridge Core)", "source": { "title": null, "citation": "Tyrer P et al. (2021), Psychological Medicine 51(10):1714-1722, DOI 10.1017/S003329172000046X", "journal": null, "year": null, "studyDesign": null, "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": null, "pubmedUrl": null, "pmcid": null, "freeFullTextUrl": null } }, { "id": "26c2eeca3830be37", "topic": "treatment", "quote": "Sample: 1,058 British adults (18-75)... 67% experience health-related anxiety overall; 27% report 'a lot or moderate amount'; 40% report 'a little'... 66% looked up symptoms online... 31% felt more anxious after symptom searching... 28% used AI chatbots for personal health information... 26% booked GP appointment [after AI chatbot use]", "quotedFrom": "poll summary", "source": { "title": null, "citation": "Ipsos poll for Good Morning Britain, 7-8 January 2026", "journal": null, "year": null, "studyDesign": null, "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": null, "pubmedUrl": null, "pmcid": null, "freeFullTextUrl": null } }, { "id": "d7958063b2f0797b", "topic": "treatment", "quote": "Effect Size: Cohen's d = 1.01 (95% CI: 0.77-1.25) at post-therapy, representing a large effect favoring CBT over control conditions... 14 were included in the meta-analysis", "quotedFrom": "abstract/results", "source": { "title": null, "citation": "Cooper K, et al. Cognitive behaviour therapy for health anxiety: A systematic review and meta-analysis. Behavioural and Cognitive Psychotherapy, 2017.", "journal": null, "year": null, "studyDesign": null, "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": null, "pubmedUrl": null, "pmcid": null, "freeFullTextUrl": null } }, { "id": "e3a24f2456e88d17", "topic": "treatment", "quote": "Following treatment, 27 of 40 (67.5%) participants who had received internet-based CBT no longer met diagnostic criteria for hypochondriasis.", "quotedFrom": "results", "source": { "title": null, "citation": "Hedman E, et al. Internet-based cognitive behaviour therapy for severe health anxiety: randomised controlled trial. British Journal of Psychiatry, 2011.", "journal": null, "year": null, "studyDesign": null, "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": null, "pubmedUrl": null, "pmcid": null, "freeFullTextUrl": null } }, { "id": "8c24a5721b08239b", "topic": "treatment", "quote": "CBT-HA showed significant advantage over standard care, with a difference of 1.83, 95% CI 0.25-3.40, p = 0.023 [on the Short Health Anxiety Inventory]... CBT-HA is a highly long-term effective treatment for pathological health anxiety with long-term benefits", "quotedFrom": "abstract/results", "source": { "title": null, "citation": "Tyrer P, et al. Cognitive behaviour therapy for health anxiety in medical patients (CHAMP): long-term follow-up to 8 years. Psychological Medicine, 2021.", "journal": null, "year": null, "studyDesign": null, "doi": null, "doiUrl": null, "doiVerifiedAgainstCrossref": false, "pmid": null, "pubmedUrl": null, "pmcid": null, "freeFullTextUrl": null } } ] }